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New natural product catathelasma imperiale sing polysaccharide CIS-A and application thereof

A natural product, CIS-A technology, applied in drug combination, anti-tumor drugs, allergic diseases, etc., can solve problems such as no reports, and achieve the ability to improve the ability, enhance the ability to phagocytose neutral red, and promote proliferation. Effect

Active Publication Date: 2017-11-07
CHINA WEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there has not been any report on the fine structure, immune activity, anti-tumor research and application of CIS-A

Method used

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  • New natural product catathelasma imperiale sing polysaccharide CIS-A and application thereof
  • New natural product catathelasma imperiale sing polysaccharide CIS-A and application thereof
  • New natural product catathelasma imperiale sing polysaccharide CIS-A and application thereof

Examples

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Embodiment 1

[0032] Example 1 Extraction, Separation and Purification of Polysaccharide CIS-A

[0033] 1.1. Extraction, separation and purification of polysaccharide CIS-A from Mushroom magnificence

[0034] 1.1.1 Extraction of crude polysaccharides from Mushroom magnifolia

[0035] Place the fruiting body of Mushroom magnificence in a constant temperature box at 65°C to dry, then crush it completely with a pulverizer, weigh 300g of the crushed powder, add distilled water and stir evenly (1:3), cook at 110°C for 6 hours, and centrifuge Collect the supernatant, repeat the cooking three times, and concentrate all the supernatant under reduced pressure, then add 3-4 times the volume of absolute ethanol to precipitate the crude polysaccharides of the Magnificent Pleurotus chinensis. The precipitate was dried and stored in a -20°C refrigerator.

[0036] 1.1.2 Separation and purification of crude polysaccharides from Mushroom magnifolia

[0037] Weigh 50g DEAE-cellulose, soak overnight in dis...

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Abstract

The invention discloses a new natural product catathelasma imperiale sing polysaccharide CIS-A and an application thereof. The catathelasma imperiale sing polysaccharide CIS-A is heteropolysaccharide composed of two monosaccharides, namely alpha-D-glucose and beta-L-galactose, in a ratio of 3:2, the average molecular weight is about 50486Da, the alpha-D-glucose connected by 1,3- and the alpha-D-glucose connected by 1,2,3- are main chains, and a side chain is the beta-L-galactose connected by two 2,3-. The catathelasma imperiale sing polysaccharide CIS-A laetiporus sulphureus polysacharride has obvious immunoregulatory activity, heteropolysaccharide CIS-A can have an obvious inhibiting effect on L929 cells cultured in vitro, and the survival rate of the cells is 68.9% when the concentration of CIS-A is 5 mu g / mL; and growth of S180 tumor is inhibited in vivo, and the inhibition ratio reaches up to 64.4%.

Description

technical field [0001] The invention belongs to the field of application technology of fungal polysaccharides, in particular, it relates to a new natural product polysaccharide CIS-A and its application. Background technique [0002] Polysaccharides are a class of biomacromolecules ubiquitous in living organisms, commonly known as polysaccharides, which are not only important substances for the formation of cytoskeleton, but also important components of various endogenous bioactive molecules. Polysaccharides have long been regarded as substances that maintain cell structures (such as cellulose and chitin) and provide energy sources (such as starch and glycogen) in organisms. The development of polysaccharides is relatively late, and polysaccharides have complex structures and diverse activities, which pose great challenges to the determination and identification of polysaccharide structures. [0003] In the past 20 years, research reports on the biological activities of pol...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P37/02A61P35/00
CPCC08B37/0087
Inventor 侯怡铃丁祥侯万儒刘露朱洪庆钱叶苟凡铖
Owner CHINA WEST NORMAL UNIVERSITY
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