Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Brucea javanica iodized oil with anti-cancer effect as well as preparation and application thereof

A technology of javanica javanica oil and iodized oil, which is applied to medical preparations containing active ingredients, active ingredients of iodine compounds, antineoplastic drugs, etc., can solve the problems of injury, liver cancer chemotherapy and radiotherapy that cannot obtain satisfactory curative effects, and achieve inhibition Effect of Hepg2 Growth

Inactive Publication Date: 2017-11-03
JIANGNAN UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy and radiotherapy for liver cancer cannot achieve satisfactory results. Chemical anticancer drugs often cause damage to other normal cells while acting on target cells, causing various side effects. Herbal medicines and traditional Chinese medicines have unique anticancer and antitumor effects. Therefore, extracting anticancer substances from natural plants has important application value and broad research prospects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Brucea javanica iodized oil with anti-cancer effect as well as preparation and application thereof
  • Brucea javanica iodized oil with anti-cancer effect as well as preparation and application thereof
  • Brucea javanica iodized oil with anti-cancer effect as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Refining of Brucea javanica oil

[0017] Heat the commercially available or extracted dark green 50g Brucea javanica oil to 70°C, add 5g of dried activated carbon, stir well and extract under reduced pressure to obtain a yellow crude oil; then heat the yellow crude oil to 70°C and add 5g of dried The kaolin is fully stirred and then extracted under reduced pressure to obtain brucea javanica oil; the obtained brucea javanica oil is bubbling with nitrogen under reduced pressure for 1 hour to obtain 48.97 g of pure brucea javanica oil.

Embodiment 2

[0018] Example 2 Quality inspection of Brucea javanica oil

[0019] (1) Determination of the content of pure Brucea javanica oil

[0020] Take 2 drops of the refined Brucea javanica oil prepared in Example 1, dissolve in 2mL NaOH methanol solution (0.5mol / L), heat to 65°C, add 2mL boron trifluoride methanol solution (1:3) after 30 minutes and heat Heat for 10 minutes at 70°C, add 2 mL of chromatographically pure n-hexane at room temperature, shake vigorously and then separate into layers. Take 1 mL of the upper organic phase, add anhydrous sodium sulfate or saturated brine, and filter with an organic filter membrane. Use GC-2010PLUS (Shimadzu) gas chromatography column, and set the gas chromatography conditions: TR-FAME 260M154P (60m×0.25mm, 0.25μm); carrier gas, high-purity nitrogen; split ratio, 100:1; sample volume 1μL; inlet temperature 250°C; detector temperature 250°C; temperature program, 60°C for 3min, 5°C / min to 175°C, holding 15min, 2°C / min to 220°C, holding 10min to the...

Embodiment 3

[0026] Example 3 Preparation of Brucea javanica iodized oil

[0027] Add 7g of red phosphorous and 70g of iodine tablets into the hydrogen iodide gas generator, add water droplets continuously at a rate of 10μL / min, heat to 40℃, and pass the generated hydrogen iodide gas into 20g pure brucea javanica oil, reaction 24 Within hours, 28.14 g of crude Brucea javanica iodized oil was obtained.

[0028] The crude iodized oil was washed with 8 mL of absolute ethanol 10 times to remove free iodine; then washed with 10 mL of sodium metabisulfite for 5 times, decolorized, and finally washed with 20 mL of distilled water for 5 times. After vacuum drying, 27.78 g of refined iodized oil was obtained.

[0029] (1) Determination of iodine content: According to the 2015 Chinese Pharmacopoeia, take 0.6g of iodized oil, place it in an evaporating dish, add 40mL KOH ethanol solution, evaporate to a mass in a water bath, wash with a small amount of water, and incorporate the washing liquid into the evap...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Half inhibitory concentrationaaaaaaaaaa
Half inhibitory concentrationaaaaaaaaaa
Half inhibitory concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses brucea javanica iodized oil with an anti-cancer effect as well as preparation and application thereof and belongs to the technical field of medicines. The brucea javanica iodized oil is characterized in that hydrogen iodide gas is introduced into brucea javanica oil for reaction to obtain the brucea javanica iodized oil. The brucea javanica iodized oil obtained by the invention has the ability to inhibit the growth of hepatoma carcinoma cells Hepg2 on the basis of having an embolization effect, can have an embolization effect in clinic and stays in a tumor area for cancer fighting.

Description

Technical field [0001] The invention relates to a Brucea javanica iodized oil with anti-cancer effect and its preparation and application, belonging to the technical field of medicine. Background technique [0002] Hepatocellular carcinoma is a common malignant tumor with high incidence in my country, with high incidence, early metastasis, poor prognosis, and lack of effective treatment methods. According to estimates by the International Cancer Research Center, a total of 2.8 million people died of cancer in China in 2015, an average of 7,500 people per day. Chemotherapy and radiotherapy for liver cancer cannot achieve satisfactory results. Chemical anti-cancer drugs often cause damage to other normal cells while acting on target cells, causing a variety of side effects, while botanicals and traditional Chinese medicines have unique anti-cancer and anti-tumor properties. Advantages, so the current anti-cancer substances extracted from natural plants have important application v...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61P35/00A61K33/18
CPCA61K33/18A61K36/185A61K2300/00
Inventor 杨兆琪仲晗实康宇
Owner JIANGNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com