Enteric coated probiotics preparation

Abstract

The invention provides an enteric coated probiotics preparation. The preparation is prepared by mixing and fermenting an aerobic bacterium and an anaerobic bacterium which are mutualistic. The aerobic bacterium is firstly inoculated in a fermentation vessel and is subjected to aerobic culture to the logarithmic phase, the oxygen is closed, the micro-aerobic fermentation continues, the anaerobic bacterium is inoculated in the process of the micro-aerobic fermentation, the aerobic bacterium and the anaerobic bacterium are in harmony and symbiosis, the culture continues under the anaerobic condition to the later period of logarithmic phase or the later period of the stable period of the anaerobic bacterium so as to obtain a fermentation product, and the fermentation product is centrifugally separated, spray-dried and coated with an enteric material to obtain the probiotics preparation. The preparation process is simple, the capacity utilization rate is high, the cost is low, the large-scale production is easy to realize; the aerobic bacterium and the anaerobic bacterium are in harmony and symbiosis in the early period in the mixing and fermenting processes, the compatibility is better; the surface of the probiotics preparation is coated with the enteric material, so that the preparation is insoluble under the environmental conditions of the gastric acid and bile, only starts to dissolve in the intestinal fluid environment, and plays a role in targeted regulation of the intestines.

Description

Technical field [0001] The invention relates to an enteric-coated probiotic preparation, which belongs to the field of microbial fermentation. Background technique [0002] Probiotic preparations, also known as microecological preparations, refer to live bacterial preparations and their metabolites that can promote the balance of the intestinal flora. Probiotic preparations contain live microorganisms, and when ingested in sufficient quantities, they can have beneficial health effects on the host. Therefore, probiotics are playing an increasingly important role in fields closely related to human life such as medicine, agriculture, industry, food and feed. [0003] Western Europe and Japan have the earliest research on probiotic preparations, with a wide variety of products and a relatively complete market. By 2004, the value of European probiotic preparations had reached US$3 billion, and consumption accounted for 5% of total food consumption; Japan approved 108 health foods (FOS...

AI Technical Summary

Problems solved by technology

This mixed anaerobic fermentation method has complex equipment and cumbersome process, the anaerobic environment must be strictly controlled, and the preparation cost is high

[0009] In summary, in the current research process of probiotic preparations, there is a lack of probiotic preparations prepared by a mixed fermentation method that combines aerobic fermentation and anaerobic fermentation. In the intestinal microenvironment, there are also problems such as poor synergy, poor compatibility, and high cost. In addition, probiotic preparations are easily affected by gastric acid and bile when they are taken orally, and live bacteria before reaching the effective site of the intestinal tract. The number will drop significantly, which will affect the curative effect or health care effect of probiotic products

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