A drug nanoparticle delivery system

Abstract

The invention relates to a drug nanoparticle delivery system comprising skeleton particles formed from solidified auxiliary materials, and drug nanoparticles wrapped in the auxiliary materials and scattered in the skeleton particles independently. The particle size of the skeleton particles is 1-10 micrometers and the average particle size of the drug nanoparticles is 50-1000 nanometers. Compared with conventional preparations, the preparations provided by the invention have a higher dissolution rate and dissolution degree. The preparations have high bioavailability when being absorbed by human bodies and are suitable for oral administration of mammals.

Description

technical field [0001] The invention relates to a drug nanoparticle delivery system, which belongs to the field of drug preparation. This system is suitable for industrial mass production. Background technique [0002] Synthetic or natural medicines treat and prevent disease and can be given by injection or orally. Compared with other drug delivery methods, oral drug delivery is more popular, causing less pain to patients, and thus has higher patient compliance. Oral administration is also a more convenient and simpler way of administration than injection administration. [0003] Many important drugs in the treatment of diseases are usually poorly water soluble drugs. Because of the low bioavailability of poorly water-soluble drugs, scientists are constantly striving to develop new formulations of such drugs to improve their solubility in the human body. An ideal drug should have the highest possible bioavailability in the human body. However, due to incomplete absorpti...

AI Technical Summary

Problems solved by technology

A disadvantage of this method is that if the active ingredient has a high melting point, high temperatures are required in the extrusion barrel to achieve sufficient dispersion of the active ingredient, and therefore higher energy consumption

[0007] The solid dispersion technology of active ingredients also includes the following disadvantages: it is not easy to scale up the laboratory formula to industrial batch production; it is difficult to control the physical and chemical properties of the drug; it is difficult to make the solid dispersion into tablets or capsules; The drug produced is not resistant to high temperatures, so special handling and storage are required; this form of the drug is very unstable

The disadvantage of this method is that a large amount of emulsifier is required to form a stable emulsion due to the inherent incompatibility of the materials

Since the droplet size is determined by the system, this method cannot accurately control the particle size of the prepared drug

Moreover, the large use of emulsifiers can cause side effects, especially on the production process and formulation of the active ingredient

[0010] The common shortcoming of the existence of the above methods is exactly the problem of scaling up to industrialized production in the pharmaceutical industry

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