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an ionization device

An ionization and uniform technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of reducing the signal-to-noise ratio of mass spectrometry signals, clogging capillaries, interrupting signals, etc., to avoid salting-out phenomenon, prevent nozzle clogging, high-intensity The effect of the noise ratio

Active Publication Date: 2019-12-31
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the existence of the solution salt system will also inhibit the ionization process, or produce high background, reduce the signal-to-noise ratio of the mass spectrometer signal, and even cause the crystallized salt to block the capillary and interrupt the signal

Method used

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Experimental program
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Effect test

Embodiment 1

[0056] Embodiment 1, ionization device

[0057] Such as Figure 1-2 As shown, the ionization device of the present invention includes: a sample capillary 3, an auxiliary liquid capillary 6 and an atomizing gas capillary 9; the sample capillary 3, the auxiliary liquid capillary 6 and the atomizing gas capillary 9 are arranged from inside to outside using the same axis. One end of the sample capillary 3 is a direct sampling interface (connected with the sample cell 2), and the other end is a sample outlet; the sample capillary 3 is near the direct sampling interface section and the auxiliary liquid capillary 6 passes through the T-shaped tee 1 5, and the sample capillary 3 The remote direct sample injection interface section, the auxiliary liquid capillary 6 and the atomizing gas capillary 9 pass through the T-shaped tee 2 8, and the setting of the three-layer casing facilitates the mixing of the sample with the auxiliary liquid during ionization, and the salt will not It is pr...

Embodiment 2

[0065] Embodiment 2, the signal amplification of citric acid solution

[0066] Use the ionization device in the embodiment of the present invention 1 to be applied to the citric acid solution, specifically as follows:

[0067] Solution preparation: use 100mM pH=7.2±0.2 mixed phosphate buffer solution as matrix to prepare 10ppm citric acid solution.

[0068] The test mode is negative ion mode. Samples were injected using a syringe pump at a flow rate of 3.5 μL / min. The spray voltage is 0.40kV. The methanol flow rate was 80 μL / min. get image 3 (a) signal. It can be seen that when methanol is turned on, the intensity of the molecular ion peak is about doubled. It shows that the ionizer of the present invention is suitable for the ionization of acidic solution.

Embodiment 3

[0069] Embodiment 3, the signal amplification of p-nitrobenzoic acid alkaline solution

[0070] Use the ionization device in the embodiment of the present invention 1 to be applied to p-nitrobenzoic acid alkaline solution, specifically as follows:

[0071] Solution preparation: add sodium hydroxide to promote the dissolution of benzoic acid, and use ultrapure water to directly prepare a 100ppm solution (calculated as benzoic acid).

[0072] The test mode is negative ion mode. Samples were injected using a syringe pump at a flow rate of 1.0 μL / min. The spray voltage is 0.30kV, the flow rate of methanol is 80μL / min, and image 3 (b) signal. It can be seen that when methanol is turned on, the peak intensity of the sample molecular ion is increased to about 10 times. It shows that the ionizer is suitable for the ionization of alkaline solution.

[0073] The signal amplification of embodiment 4, sodium dodecyl sulfate (SDS) and saline solution

[0074] Use the ionization devi...

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Abstract

The invention discloses an ionizing device, which comprises a sample capillary tube, an auxiliary liquid capillary tube and an atomizing gas capillary tube, wherein the sample capillary tube, the auxiliary liquid capillary tube and the atomizing gas capillary tube are arranged coaxially from inner to outer side; a direct sample inlet is arranged at one end of the sample capillary tube while a sample outlet is arranged at the other end; a proximal direct sample inlet section of the sample capillary tube and the auxiliary liquid capillary tube are penetrated through a T-shaped tee joint 1; a distal direct sample inlet section of the sample capillary tube, the auxiliary liquid capillary tube and the atomizing gas capillary tube are penetrated through a T-shaped tee joint 2; an auxiliary liquid port formed on the auxiliary liquid capillary tube is connected with an auxiliary liquid injection pipe through a vertical port of the T-shaped tee joint 1; an atomizing gas port formed on the atomizing gas capillary tube is connected with an atomizing gas injection pipe through the vertical port of the T-shaped tee joint 2; an ionizing high pressure port is formed on the sample capillary tube; and an electrode of a high voltage power supply is connected with the ionizing high pressure port. The ionizing device has a simple structure, is high in ionizing efficiency, can avoid salt effect and can acquire higher signal to noise ratio of a mass spectrum signal.

Description

technical field [0001] The invention relates to an ionization device, which belongs to the field of organic spectrum analysis. Background technique [0002] Mass spectrometry is a means of ionizing substances and characterizing them by determining the mass-to-charge ratio of the ions. Since most macroscopic substances are electrically neutral or nearly electrically neutral, and such substances cannot be separated by an electric field or a magnetic field, an ion current is generated and detected. Therefore, it is necessary to ionize the sample before entering the mass spectrometer for detection, and then enter the mass spectrometer for detection. An electrospray ionizer (ESI) is a traditional ion source. It is mainly used in liquid chromatography-mass spectrometry, which is not only an interface device between liquid chromatography and mass spectrometer, but also an ionization device. It is mainly composed of an electrospray nozzle composed of a multi-layer casing. The inn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/68
CPCG01N27/68
Inventor 那娜王岩欧阳津
Owner BEIJING NORMAL UNIVERSITY
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