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Preparation method of ferroferric oxide/ titanium dioxide magnetic biological activity coating

A technology of ferroferric oxide and titanium dioxide, applied in coatings, surface reaction electrolytic coatings, electrolytic coatings, etc., can solve problems such as implant failure, insufficient biological activity, and weak tissue bonding, so as to promote new bone formation, Good biological activity, promote integration effect

Active Publication Date: 2017-10-10
汉中艾斯达特新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still problems such as insufficient biological activity in clinical application, and it is easy to form enveloping fibrous membrane after implantation in the body, which is not firmly combined with the tissue, resulting in implantation failure.

Method used

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  • Preparation method of ferroferric oxide/ titanium dioxide magnetic biological activity coating
  • Preparation method of ferroferric oxide/ titanium dioxide magnetic biological activity coating
  • Preparation method of ferroferric oxide/ titanium dioxide magnetic biological activity coating

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preparation example Construction

[0027] A preparation method for ferroferric oxide / titanium dioxide magnetic bioactive coating, comprising the following steps:

[0028] Step 1: using solvothermal method, using ethylene glycol as solvent, 1,6-hexamethylenediamine, ferric chloride hexahydrate, and anhydrous sodium acetate as solutes, wherein the concentration of 1,6-hexamethylenediamine is 0.2–5.0 mol / L, the concentration of ferric chloride hexahydrate is 0.05-2.0mol / L, the concentration of anhydrous sodium acetate is 0.01-0.5mol / L, the reaction is carried out in a high temperature and high pressure reactor, the reaction temperature is 180-220°C, the time 2-24h, after the reaction is completed, water-soluble aminated ferric oxide nanoparticles with a particle size of 20-300nm are obtained;

[0029] Step 2: Using micro-arc oxidation method, water is used as solvent, and water-soluble aminated ferric oxide nanoparticles, calcium salt, phosphorus salt and weak acid are used as solute to form an electrolyte, and wa...

Embodiment 1

[0032] Step 1: Prepare 180mL of a solution with 1,6-hexanediamine, ferric chloride hexahydrate, anhydrous sodium acetate as the solute and ethylene glycol as the solvent, wherein the concentration of 1,6-hexanediamine is 1.4mol / L, the concentration of ferric chloride hexahydrate is 0.1mol / L, and the concentration of anhydrous sodium acetate is 0.06mol / L, then transfer the above solution into a 250mL high-temperature and high-pressure reactor, and keep it warm for 6 hours at 198°C to prepare Water-soluble aminated ferric oxide nanoparticles with a size of 160nm were obtained.

[0033] The second step: in the composite solution of 0.2mol / L calcium acetate, 0.2mol / L β-sodium glycerophosphate and 0.167mol / L acetic acid, add 5.0g of the above-mentioned aminated ferric oxide nanometer Particles form an electrolyte, with titanium as the anode and stainless steel as the cathode, using a pulse power supply to conduct micro-arc plasma treatment on titanium under the conditions of volta...

Embodiment 2

[0035] Step 1: Prepare 180mL of a solution with 1,6-hexanediamine, ferric chloride hexahydrate, anhydrous sodium acetate as the solute and ethylene glycol as the solvent, wherein the concentration of 1,6-hexanediamine is 0.2mol / L 1,6-hexamethylenediamine, the concentration of ferric chloride hexahydrate is 2.0mol / L, and the concentration of anhydrous sodium acetate is 0.01mol / L. The water-soluble aminated ferric oxide nanoparticles with a size of 20 nm can be prepared by keeping the temperature for 2 hours.

[0036] Second step: in the composite solution of the calcium chloride by 0.5mol / L, the sodium phosphate of 0.5mol / L and 0.01mol / L oxalic acid, add the above-mentioned aminated ferric oxide nanoparticles of 0.2g, An electrolyte is formed, with titanium as the anode and stainless steel as the cathode, using a pulse power supply to conduct micro-arc plasma treatment on titanium under the conditions of voltage 550V, frequency 350Hz, duty cycle 5%, and distance between cathod...

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Abstract

The invention discloses a preparation method of a ferroferric oxide / titanium dioxide magnetic biological activity coating. The preparation method comprises the steps of firstly, utilizing a solvent-thermal method, adopting ethylene glycol as a solvent, adopting 1,6-hexamethylenediamine, ferric trichloride hexahydrate and anhydrous sodium acetate as solutes, reacting in a reaction kettle, and obtaining water-soluble aminated ferroferric oxide magnetic nanoparticles after finishing reaction; secondly, adopting a microplasma oxidation method, adopting water as a solvent, adopting the water-soluble aminated ferroferric oxide magnetic nanoparticles, calcium salt, phosphor salt and weak acid as solutes, and forming an electrolyte solution; and adopting a titanium / titanium alloy sample as an anode and stainless steel as a cathode, adopting a pulse power supply for carrying out microplasma oxidation treatment on the titanium / titanium alloy sample, and after finishing reaction, generating the ferroferric oxide / titanium dioxide magnetic biological activity coating on a surface layer of the titanium / titanium alloy sample. The magnetic material can respond to an external magnetic field, a magnetocaloric effect is produced through the external alternating magnetic field so as to heat up a focus area, and tumor cells are killed, so that the function of bone cancer magnetic hyperthermia is realized.

Description

technical field [0001] The invention relates to the field of surface modification of titanium and titanium alloy components, in particular to a preparation method of ferric oxide / titanium dioxide magnetic bioactive coating. Background technique [0002] The use of magnetic fields to treat bone tissue diseases has long been widely carried out clinically. A large number of research results show that the external magnetic field can promote the proliferation and differentiation of osteoblasts, thereby promoting the formation of new bone, and can also promote the integration of implants and bone, increase bone density and calcium content, and promote fracture healing. However, traditional magnetic therapy usually requires complex equipment, which is inconvenient to use and carry, which greatly limits its application. [0003] Magnetic nanoparticles have gradually attracted extensive attention of scientific researchers because of their potential application prospects in protein s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/30A61L27/54
CPCA61L27/06A61L27/306A61L27/54C25D11/26
Inventor 张兰李凯憨勇
Owner 汉中艾斯达特新材料科技有限公司
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