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Pharmaceutical composition for treating diabetic peripheral neuropathy

A technology of peripheral neuropathy and composition, which is applied in the direction of drug combination, nervous system disease, metabolic disease, etc., can solve the problems of vacancy, poor compliance with taking, inconvenient diabetic peripheral neuropathy, etc., and achieve simple and clear chemical composition and remarkable effect Effect

Inactive Publication Date: 2017-09-29
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Modern traditional Chinese medicines are often used to treat diabetic peripheral neuropathy with decoctions, which are poor in compliance and inconvenient to carry and store.

Method used

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  • Pharmaceutical composition for treating diabetic peripheral neuropathy
  • Pharmaceutical composition for treating diabetic peripheral neuropathy
  • Pharmaceutical composition for treating diabetic peripheral neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Prescription: Astragalus Pueraria Radix Glycosides effective fraction 200g Angelica total phenolic acid effective fraction 80g Corydalis total alkaloids effective fraction 30g malt Spatholobus Spatholobus water-soluble effective fraction 300g

[0084] Preparation method: Preparation of total glycosides of Radix Astragali and Pueraria Radix Radix Radix Radix Radix Radix Radix Astragali, Radix Pueraria Radix Radix Radix Radix Radix Radix Astragali and rhizome of Radix Rehmanniae Rhizome, crushed and added 10 times the amount of 70% ethanol to reflux for extraction twice, each time for 2 hours, combined ethanol extracts to recover solvent, dried to obtain ethanol extraction After the ethanol extract was dissolved in a small amount of water, it was eluted by D101 macroporous adsorption resin column, firstly with water, then with 80% ethanol, combined with the ethanol eluent, recovered the solvent, and dried to obtain total glucosides of Astragalus puerarin ; wherein the cont...

Embodiment 2

[0089] Prescription: Total glucosides of Astragalus Puerariae Radix 400g Angelica total phenolic acid 160g Corydalis total alkaloids 60g

[0090] Water-soluble active part of Malt Mildew Spatholobus 600g

[0091] Preparation method: Preparation of total glucosides of Radix Astragalus and Pueraria Radix: Take Radix Astragali, Radix Puerariae and Rhizome of Radix Rehmanniae, crush them, add 1 times the amount of 70% ethanol to reflux extraction twice, each time for 2 hours, combine the ethanol extracts to recover the solvent, and dry to obtain ethanol extraction After the ethanol extract was dissolved in a small amount of water, it was eluted by D101 macroporous adsorption resin column, firstly with water, then with 80% ethanol, combined with the ethanol eluent, recovered the solvent, and dried to obtain total glucosides of Astragalus puerarin ; wherein the content of astragaloside IV is 0.1% to 0.3%, and the content of puerarin is 10% to 15%;

[0092] Preparation of total phen...

Embodiment 3

[0097] Prescription: Total glycosides of Radix Astragalus and Pueraria Radix 2kg, total phenolic acids of Angelica 0.8kg, total alkaloids of Corydalis 0.3kg

[0098] Water-soluble active parts of Malt Mildew Spatholobus 3kg

[0099] Preparation method: Take the above-mentioned effective parts, crush, mix, add 600g of lactose, add starch to 10kg, mix well, granulate, pack separately, and get it. Specification: 10g / bag. Example 4:

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Abstract

The invention discloses a pharmaceutical composition for treating diabetic peripheral neuropathy and belongs to the field of traditional Chinese medicines. The composition is prepared from total glycosides extracted from radix astragali seu hedysari, radix puerariae and radix rehmanniae, total phenolic acid extracted from Chinese angelica root, total alkaloid extracted from rhizoma corydalis and water-soluble components extracted from malts and caulis spatholobi according to a certain ratio; pharmaceutical conventional auxiliary materials are added into the composition to prepare various preparations and the pharmaceutical composition can be clinically used for treating the diabetic peripheral neuropathy.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has the function of treating diabetic peripheral neuropathy and preparation method thereof, specifically Chinese medicine effective part composition and its The preparation method belongs to the field of traditional Chinese medicines. Background technique [0002] Diabetic Peripheral Neuropathy (DPN) is one of the most common chronic complications among many diabetic complications. Since the 19th century, the incidence of diabetic peripheral neuropathy has increased significantly due to changes in human behavior and lifestyle. A study in the UK pointed out that at least one tenth of the patients had been combined with DPN when they were diagnosed with diabetes. At present, about half of diabetic patients in our country suffer from DPN. Diabetic peripheral neuropathy develops slowly, and the inconspicuous symptoms at the beginning will gradually involve the nervous system, such as m...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P3/10A61P25/02
CPCA61K36/232A61K36/481A61K36/486A61K36/488A61K36/66A61K36/804A61K36/8998A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 孙志强代龙韩宇嘉
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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