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Preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles

A technology of magnetic nanoparticles and encapsulation of polydopamine, which is used in pharmaceutical formulations, medical preparations containing active ingredients, anti-tumor drugs, etc., to improve the therapeutic effect, solve the effect of targeting and synergy

Inactive Publication Date: 2017-09-29
SOUTHWEST UNIVERSITY
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  • Abstract
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Problems solved by technology

However, it is difficult for a single treatment to completely eliminate tumor cells, therefore, due to the synergistic effect, the combination of photothermal therapy and chemotherapy is promising to obtain an enhanced anti-tumor effect

Method used

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  • Preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles
  • Preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles
  • Preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles

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Embodiment 1

[0028] Example 1 Preparation of PEGylated Drug-loaded Magnetic Nanoparticles Encapsulating Polydopamine

[0029] (1) Fe 3 o 4 Preparation of @PDA magnetic composite material: Dissolve 0.556g of ferrous sulfate heptahydrate and 1.04g of ferric chloride hexahydrate in 5mL of deionized water, add 0.17mL of concentrated hydrochloric acid, and add the mixed solution dropwise to 50mL of 1.5M hydroxide Stir vigorously in the sodium solution at 80°C under nitrogen protection for half an hour, cool to room temperature naturally, and wash the magnetic separation with deionized water for 3 times. Fe 3 o 4 Nanoparticles were dispersed in pH=8.5, 10mM Tris buffer solution, mechanically stirred at room temperature for 12 hours, magnetically separated, and washed three times with deionized water.

[0030] (2) PEGylated Fe 3 o 4 Preparation of @PDA: Add 100mg thiol polyethylene glycol to 40mL 1mg / mLFe 3 o 4 @PDA nanoparticle suspension, after stirring for 5 minutes, add 0.2mL ammonia w...

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Abstract

The invention relates to the field of synthesis of pharmaceutical chemistry and particularly relates to a specific method for ferroferric oxide, PDA-coated ferroferric oxide, pegylation and final drug-loading and various steps. A preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles specifically comprises the following steps: (1) synthesizing ferroferric oxide by adopting an alkaline coprecipitation method; (2) carrying out auto-polymerization on dopamine under an alkaline condition in the presence of the ferroferric oxide; (3) pegylating PDA-coated magnetic nanoparticles; and (4) carrying anti-cancer drug adriamycin to the magnetic nanoparticles by using hydrophobic interaction. The obtained composite nanodrug delivery system has the advantages of targeting delivery, high drug loading capacity and good biocompatibility.

Description

technical field [0001] The invention relates to the field of chemical drugs, in particular to the preparation and application of pegylated dopamine-coated drug-loaded magnetic nanoparticles with targeting effect and synergistic therapy. Background technique [0002] Doxorubicin (Doxorubicin, DOX, another name: doxorubicin; afariamycin, etc., chemical structural formula: C 27 h 29 NO 11 , CAS number: 23214-92-8, relative molecular weight: 543.52) is an anthracycline anti-tumor antibiotic produced by Streptomyces persei subsp. more sensitive. Hydrochloride is orange-red needle crystal. The melting point is 204-205°C. Soluble in water, ethanol, methanol. It is an antitumor antibiotic isolated from the culture medium of Actinomycetes. The mechanism of action is similar to that of daunorubicin, and its antitumor spectrum is wider and its therapeutic index is higher. Clinical application in acute and chronic lymphocytic leukemia and solid tumor leukemia, lymphoma, breast c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K31/704A61K47/02A61K47/10A61K47/34A61P35/00
Inventor 薛鹏孙利红康跃军李倩张蕾许志刚
Owner SOUTHWEST UNIVERSITY
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