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Preparation for preventing and treating hyperostosis, rheumatic osteoarthritis, arthralgia and myalgia and preparation method thereof

A technology for osteoarthritis and osteoarthritis, applied to preparations for rheumatoid osteoarthritis and musculoskeletal pain and preparation thereof, in the field of prevention and treatment of osteoarthritis, and can solve the problem of no occurrence of osteoarthritis and rheumatoid osteoarthritis Muscle and bone pain, reducing the types of compatibility of traditional Chinese medicines, prohibitive and other problems, to achieve the effect of diversification, realization of preparation types, and satisfaction of needs

Inactive Publication Date: 2017-09-22
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But at present Clematis is used in the treatment of related bone diseases in the form of compound preparations. For example, Chinese patent CN1879846 discloses a Chinese medicine preparation for the treatment of rheumatism, hyperosteogeny and osteoporosis. Composed of Pueraria lobata, Epimedium, Papaya, Achyranthes bidentata, Codonopsis pilosula, Turmeric, Clematis, Psoralen, starch, sodium carboxymethyl starch and talcum powder, the Chinese medicine preparation contains a wide variety of traditional Chinese medicines, including valuable medicinal materials, and its price Consumers are discouraged; Chinese patent CN105362540A provides a Chinese medicine combination for the treatment of bone hyperplasia, which is prepared by mixing Lubiancao, Clematis, Raw Southern Star, Raw Licorice, Gentiana, Borneolum, and white vinegar. The type of Chinese medicine compatibility effectively reduces the cost, but Clematis in this Chinese medicine combination still needs to cooperate and synergize with other drug components
[0005] At present, there are no reports of using Clematis alone to treat hyperosteogeny, rheumatic osteoarthritis, and muscle and bone pain.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment is the preparation of Wei Lingxian injection, and its steps are as follows:

[0031] Clematis 1.0 kg, add 5 times the amount of distilled water, soak at 50 degrees Celsius for 12 hours, then distill at 100 degrees Celsius for 4 hours, collect 2000 ml of distillate; distill the distillate at 100 degrees Celsius for 2 hours, collect about 900 ml of distillate; add A total of 5 ml of polysorbate 80, heated to dissolve, shaken and filtered, adjusted to pH 6.0, distilled water to 1000 ml, filtered, potted, steam sterilized to obtain Clematis injection. The identification method of Clematis Injection is to take 1 ml of the distillate after heavy distillation, add distilled water to dilute to 50 ml, shake well, and detect the maximum absorption at the wavelength of 255±3nm by ultraviolet-visible spectrophotometry. Each Clematis injection is 2ml, intramuscular injection, 2-4ml each time, 1-2 times a day.

Embodiment 2

[0033] This embodiment is the preparation of Wei Lingxian injection, and its steps are as follows:

[0034] Clematis 1.0 kg, add 10 times the amount of distilled water, soak at 60 degrees Celsius for 6 hours, then distill at 100 degrees Celsius for 8 hours, collect 4000 ml of distillate; distill the distillate at 100 degrees Celsius for 3 hours, collect about 900 ml of distillate; add A total of 5 ml of polysorbate 80, heated to dissolve, shaken and filtered, adjusted to pH 6.0, distilled water to 1000 ml, filtered, potted, steam sterilized to obtain Clematis injection. The identification method of Clematis Injection is to take 1 ml of the distillate after heavy distillation, add distilled water to dilute to 50 ml, shake well, and detect the maximum absorption at the wavelength of 255±3nm by ultraviolet-visible spectrophotometry. Each Clematis injection is 2ml, intramuscular injection, 2-4ml each time, 1-2 times a day.

Embodiment 3

[0036] This embodiment is the preparation of Wei Lingxian injection, and its steps are as follows:

[0037] Clematis 1.0 kg, add 10 times the amount of distilled water and soak at 40 degrees Celsius for 24 hours, then distill at 100 degrees Celsius for 4 hours, collect 2000 ml of distillate; distill the distillate at 100 degrees Celsius for 2 hours, collect about 900 ml of distillate; add A total of 5 ml of polysorbate 80, heated to dissolve, shaken and filtered, adjusted to pH 6.0, distilled water to 1000 ml, filtered, potted, steam sterilized to obtain Clematis injection. The identification method of Clematis Injection is to take 1 ml of the distillate after heavy distillation, add distilled water to dilute to 50 ml, shake well, and detect the maximum absorption at the wavelength of 255±3nm by ultraviolet-visible spectrophotometry. Each Clematis injection is 2ml, intramuscular injection, 2-4ml each time, 1-2 times a day.

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Abstract

The invention discloses preparation for preventing and treating hyperostosis, rheumatic osteoarthritis, arthralgia and myalgia. A preparation method of the preparation comprises the following steps of extracting and refining radix clematidis volatile oil components and preparing radix clematidis volatile oil preparation, wherein radix clematidis volatile oil extraction includes a distillation method and a solvent extraction method, and the obtained radix clematidis volatile oil components include at least one of aromatic water and volatile oil which are obtained by steam distillation and radix clematidis volatile oil prepared by the solvent extraction method. According to the preparation method disclosed by the invention, the step of extracting and refining radix clematidis volatile oil components is optimized, so that the prepared preparation containing single radix clematidis volatile oil component is especially suitable for preventing and treating the hyperostosis, the rheumatic osteoarthritis, the arthralgia and the myalgia; furthermore, preparation diversity is achieved, a patient can choose plastics, transdermal patch and paste to replace injection, times of the patient to go to hospital back and forth are reduced, and requirement of patients is met.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation for preventing and treating hyperosteogeny, rheumatic osteoarthritis and muscle and bone pain and a preparation method thereof. Background technique [0002] Clematis, Ranunculaceae, Clematis perennial woody vines. Clinically, it is used to treat gout and stubborn numbness, numbness of limbs, spasm of tendons, weaken rheumatic arthralgia, relax tendons and activate blood circulation, reduce swelling and relieve pain, etc. It is widely used clinically to treat rheumatic pain, falls, bone Hyperplasia and rheumatoid arthritis and other diseases. [0003] The chemical composition of clematis includes volatile and non-volatile components. Some scholars used steam distillation to extract volatile components in Clematis clematis and analyzed and identified them by GC-MS technology, and found that its chemical components are mainly fatty ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61P19/02A61P19/08A61P29/00
CPCA61K36/716A61K2236/331
Inventor 杨全军
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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