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Preparation method of peony composite flavone dropping pills

A compound flavonoid and paeonol flavonoid technology, which is applied in the direction of medical preparations containing active ingredients, pill delivery, drug combination, etc., can solve the problems of unfavorable industrial production, complicated extraction process, and long extraction time

Inactive Publication Date: 2021-09-14
丁新年
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when extracting the flavonoid essence in peony, the extraction process was complicated and the extraction time was relatively long, especially in the flavonoid crude extraction process.
Rough extraction generally takes 2 to 4 hours, and some even take longer, which is not conducive to industrial production

Method used

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  • Preparation method of peony composite flavone dropping pills

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of preparation method of peony compound flavonoid dropping pill, concrete preparation steps are as follows:

[0036] 1. Extract total flavonoids from peony petals:

[0037] 1), sort the picked fresh peony petals, dry in the shade for 1 hour, then dry, pulverize, and pass through a 100-mesh sieve to obtain peony petal powder. In this embodiment, red peony petals and Danfeng white peony petals are used as peony petals, preferably, the volume ratio of red peony petals to Danfeng white peony petals is 3:1.

[0038]Studies have shown that the extract of peony petals has a scavenging rate of more than 80% for DPPH free radicals, and for superoxide anion O - 2 The scavenging rate of hydroxyl radicals (·OH) is generally 54-58%. Compared with natural plants, the extract of peony petals has a stronger ability to remove lipid peroxides, and has less toxic and side effects. Moreover, the activity of the red peony petal extract in scavenging oxygen free radicals is better...

Embodiment 2

[0078] A kind of preparation method of peony compound flavonoid dropping pill, concrete preparation steps are as follows:

[0079] 1. Extract total flavonoids from peony petals:

[0080] 1), sort the picked fresh peony petals, dry in the shade for 1 hour, then dry, pulverize, and pass through a 100-mesh sieve to obtain peony petal powder.

[0081] 2), mix the peony petal powder with ethanol, the volume ratio of material to liquid is 1:16, and the ethanol concentration is 70%, stir well and pour into the flash extractor for extraction, the extraction time is 2min, the rotating speed is 3000r / min, and the liquid temperature is < At 45°C, the residue was filtered out to obtain the flash extraction mixture of peony petals. Mix the filtered residue with 75% ethanol, the volume ratio of solid to liquid is 1:12, pour it into the flash extractor for 2 extractions, the extraction time is 2min, the rotation speed is 3000r / min, and the liquid temperature is <45°C , filter out the resid...

Embodiment 3

[0115] A kind of preparation method of peony compound flavonoid dropping pill, concrete preparation steps are as follows:

[0116] 1. Extract total flavonoids from peony petals:

[0117] 1), sort the picked fresh peony petals, dry in the shade for 1 hour, then dry, pulverize, and pass through a 100-mesh sieve to obtain peony petal powder. In this embodiment, red peony petals and Danfeng white peony petals are used as the peony petals, and the volume ratio of the red peony petals to the Danfeng white peony petals is 1:1.

[0118] 2), mix peony petal powder with ethanol, the volume ratio of material to liquid is 1:20, and the ethanol concentration is 70%, stir well and pour into the flash extractor for extraction, the extraction time is 3min, the rotating speed is 7000r / min, and the liquid temperature is < At 50°C, the residue was filtered out to obtain the flash extraction mixture of peony petals. Mix the filtered residue with 75% ethanol, the volume ratio of solid to liquid ...

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Abstract

The invention discloses a preparation method of peony composite flavone dropping pills, and belongs to the technical field of flavone extraction. The method comprises the following steps: respectively extracting and processing three raw materials, namely peony petals, peony stamens and paeonia suffruticosa, so as to obtain peony petal flavone purified paste, peony stamen flavone purified paste and paeonia suffruticosa flavone purified paste, then organically combining the three flavone purified paste according to the difference of nutritional ingredients of the three flavone purified paste, and processing to obtain the peony composite flavone dropping pills. The processes of flash extraction, vacuum concentration, centrifugal separation, filtration and purification, macroporous resin column adsorption and the like are adopted in the preparation process. The preparation method is easy to operate, high in guidance quality, high in flavone extraction rate, short in extraction time and very suitable for industrial application and popularization, and the flavone dropping pills prepared through the method are good in health care effect.

Description

technical field [0001] The invention belongs to the technical field of flavonoid extraction, in particular to a preparation method of peony compound flavonoid dropping pills. Background technique [0002] Peony is a traditional Chinese medicinal material in my country. It is recorded in ancient Chinese medical classics "Shen Nong's Materia Medica", "Hua Tuo Qian Jin Fang", "Treatise on Febrile and Miscellaneous Diseases", and "Compendium of Materia Medica". The three meridians of the liver and kidney, regulate the body's qi and blood, activate the body's meridians and eliminate turbidity, store essence and suppress evil, calm the five internal organs, and prolong life. [0003] Peony has a variety of vitamins, amino acids, minerals, flavonoids and polyphenols. Modern biological research has found that the anthocyanins, nutrients, and essences of tea peony are mainly contained in flavonoids and polysaccharide media. [0004] Peony petals are rich in flavonoids and polyphenol...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61K9/20A61P9/10A61P3/06A61P9/00A61K133/00A61K129/00
CPCA61K36/71A61K36/65A61K9/20A61P9/10A61P3/06A61P9/00A61K2236/333A61K2236/55A61K2300/00
Inventor 丁新年
Owner 丁新年
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