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A kind of microfibrous collagen hemostatic material and preparation method thereof

A hemostatic material and microfiber technology, which is applied in the fields of surgery, surgical adhesives, medical science, etc., can solve the problems of gelatin sponge wound tissue adhesion, poor hemostatic effect, easy to break and fall off, etc., and achieve wound tissue adhesion Good, not easy to quickly absorb, prevent the effect of oxidative denaturation of materials

Active Publication Date: 2020-10-02
林贵梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, fibrin glue is widely used in hemostasis in clinical operations, but the components of fibrin glue are blood products, which have the risk of antigenicity and viral disease transmission, and its application safety has been questioned, and the cost is high; gelatin sponge The wound tissue of oxidized cellulose has poor adhesion, is easy to rupture and fall off, and has a poor hemostatic effect on large bleeding; oxidized cellulose is loose and can be absorbed by the body quickly, but it may cause rebleeding, and the high acid environment produced by it will pass through A diffuse chemical mechanism causes nerve damage; chitosan, carboxymethyl chitosan, alginic acid, and modified starch are natural polysaccharides, which have problems such as poor batch stability and difficult quality control in production

Method used

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  • A kind of microfibrous collagen hemostatic material and preparation method thereof
  • A kind of microfibrous collagen hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 1. Depilate cowhide with a depilatory agent containing 4wt% sodium sulfide and 40vol% ethanol.

[0073]2. Cut raw bovine leather into 3.0cm squares and freeze for later use.

[0074] 3. Thaw for 1 day, wash with 2-8°C aqueous solution for several times, and after removing excess water, use a cutting machine to cut the cowhide into small pieces or pieces of 0.60-1.50cm.

[0075] 4. The cut pieces are mixed with crushed ice and then fiberized by a cutting machine, so that the solid content after fiberization is 35 wt%, and centrifuged to make the solid content 40 wt%.

[0076] 5. All liquid handling is carried out between 25-28°C. To 12.5 kg of the fibrillation mixture was added a mixture of 37.5 kg of ethanol and 200 mL of 12N hydrochloric acid (concentrated hydrochloric acid). Mix and stir for 5 hours, and centrifuge to make the solid content 50wt%.

[0077] 6. Add 31.7kg of ethanol and 317g of Tween 80 mixture to the above centrifuged mixture, mix and stir for 3h, a...

Embodiment 2

[0083] 1. adopt the depilatory agent that contains 4wt% sodium sulfide, 40vol% ethanol to depilate cowhide,

[0084] 2. Cut raw bovine leather into 3.0cm squares and freeze for later use.

[0085] 3. Thaw for 1 day, wash with 2-8°C aqueous solution for several times, and after removing excess water, use a cutting machine to cut the cowhide into small pieces or pieces of 0.60-1.50cm.

[0086] 4. The cut pieces are mixed with crushed ice and then fiberized by a cutting machine, so that the solid content after fiberization is 35%, and centrifuged to make the solid content 40wt%.

[0087] 5. All liquid handling is carried out between 25-28°C. To 12.5 kg of the fibrillation mixture was added a mixture of 37.5 kg of ethanol and 200 mL of 12N hydrochloric acid (concentrated hydrochloric acid). Mix and stir for 5 hours, and centrifuge to make the solid content 50wt%.

[0088] 6. Add 31.7 kg of ethanol and 317 g of Tween 80 mixture to the above centrifuged mixture, mix and stir for ...

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Abstract

The invention relates to a microfiber collagen hemostatic material and a preparation method thereof. The preparation method of the material includes the first step of sodium sulfide unhairing, the second step of shredding and fibrosis, the third step of swelling control, the fourth step of drying, the fifth step of depolymerisation and fluffing, and the sixth step of Co60 radiation sterilization, wherein in the fifth step, the obtained fasciculus is treated using a hammer mill to obtain a microfiber collagen product. According to the method, the use concentration of sodium sulphide is reduced, the efficiency of unhairing is improved, and degreasing and impure protein removal are effectively conducted; collagen materials are not oxidized and degenerated, the activity of microfiber collagen is easy to maintain, and the hemostatic effect is improved. Acid is introduced in the treating process, the degreasing and protein removal are more effective, and the adhesion property of the hemostatic material is guaranteed.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular, the invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] The statistical results of clinical practice show that injury or uncontrollable postoperative bleeding is the main cause of death. Hemostasis means are very important in the medical field. Before hemostasis and complete hemostasis, it is very important to shorten the hemostasis time and reduce the amount of blood loss. If the bleeding cannot be completely stopped, the bleeding during the operation will affect the vision and increase the difficulty of the operation, and the bleeding after the operation will lead to infection, which will lead to difficulties in post-operative care and even reoperation. In recent years, medical absorbable hemostatic materials have attracted great attention from the medical and industrial circles of various countries. Many large pharmaceutica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00A61L2/08
CPCA61L2/0029A61L24/0042A61L24/102
Inventor 林贵梅
Owner 林贵梅
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