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Valeriana jatamansi volatile oil antibacterial agent clathrate and preparation method thereof

A technology of spider incense and volatile oil, which is applied in the direction of antibacterial drugs, essential oils/fragrances, pharmaceutical formulas, etc. It can solve the problems of accelerating the active ingredients of drugs, not being suitable for industrial production, and high equipment costs, so as to achieve lower boiling point, high extraction rate, time-consuming effect

Inactive Publication Date: 2017-08-22
云南龙发制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The critical temperature of carbon dioxide in supercritical fluid extraction is relatively low, so it is ideal for heat-sensitive components and can improve the quality of volatile oil, but the equipment cost is high and the operation is complicated
Ultrasonic-assisted extraction and microwave-assisted extraction can both accelerate the active ingredients of drugs into the solvent, thereby improving the extraction efficiency, but these two methods are not suitable for large-scale industrial production at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: The antibacterial agent clathrate of the volatile oil of spider incense was extracted by vacuum distillation, and then β-cyclodextrin was used as an embedding agent, and ultrasonically assisted by embedding, wherein β-cyclodextrin The mass-to-volume ratio of the volatile oil of spider incense is 6:1.

[0028] The specific steps of the preparation method of the above-mentioned spider incense volatile oil antibacterial agent inclusion compound are as follows:

[0029] (1) Slice the spider incense raw material, crush and sieve to 20 mesh;

[0030] (2) Add 8 times the mass of distilled water to the sifted spider incense powder, and reflux extraction at 50°C for 12 hours;

[0031] (3) After reflux extraction, under the conditions of 55°C and a pressure of 0.086MPa, vacuum distillation extracts the volatile oil, and after collection, the volatile oil of spider scent is obtained, and the oil yield of spider scent is 0.75%;

[0032] (4) Dissolve β-cyclodextrin in d...

Embodiment 2

[0036] Example 2: The antibacterial agent clathrate of the volatile oil of spider incense is extracted by vacuum distillation, and then the β-cyclodextrin is used as the embedding agent, and the embedding is assisted by ultrasound, wherein the β-cyclodextrin The mass-to-volume ratio of the volatile oil of spider incense is 8:1.

[0037] The specific steps of the preparation method of the above-mentioned spider incense volatile oil antibacterial agent inclusion compound are as follows:

[0038] (1) Slice the spider incense raw material, crush and sieve to 30 mesh;

[0039] (2) Add 10 times the mass of distilled water to the sieved spider incense powder, and reflux extraction at 60°C for 10 hours;

[0040] (3) After reflux extraction, under the conditions of 60°C and a pressure of 0.088MPa, vacuum distillation extracts the volatile oil, and after collection, the volatile oil of spider scent is obtained, and the oil yield of spider scent is 0.1%;

[0041](4) Dissolve β-cyclodex...

Embodiment 3

[0045] Example 3: The antibacterial agent clathrate of the volatile oil of spider incense was extracted by vacuum distillation, and then β-cyclodextrin was used as embedding agent, and ultrasonically assisted in embedding, wherein β-cyclodextrin The mass-to-volume ratio of the volatile oil of spider incense is 10:1.

[0046] The specific steps of the preparation method of the above-mentioned spider incense volatile oil antibacterial agent inclusion compound are as follows:

[0047] (1) Slice the spider incense raw material, crush and sieve to 20 mesh;

[0048] (2) Add 12 times the mass of distilled water to the sifted spider incense powder, and reflux extraction at 70°C for 6 hours;

[0049] (3) After reflux extraction, under the condition of 60°C and pressure of 0.09MPa, vacuum distillation extracts the volatile oil, and after collection, the volatile oil of spider scent is obtained, and the oil yield of spider scent is 0.9%;

[0050] (4) Dissolve β-cyclodextrin in distille...

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Abstract

The invention discloses a Valeriana jatamansi volatile oil antibacterial agent clathrate and a preparation method thereof. The clathrate is prepared by the following steps: a reduced pressure distillation method is used for extracting Valeriana jatamansi volatile oil, beta-cyclodextrin is used as an embedding medium, embedding is carried out with auxiliary ultrasonic treatment, and the clathrate is obtained. The reduced pressure distillation method is used for extracting Valeriana jatamansi volatile oil; because Valeriana jatamansi has the disadvantages of easy volatilization, strong stink, bad stability, and the like, which influences clinic application thereof, beta-cyclodextrin is used as the embedding medium for carrying out embedding, and smell and efficacy of the Valeriana jatamansi volatile oil are improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an antibacterial agent clathrate of spider incense volatile oil and a preparation method thereof. Background technique [0002] Spider Incense ( Valeriana jatamansi Jones.) is a plant of the genus Valeriana in the family Pattenaceae, also known as horseshoe incense, soil asarum, ghosts, Leigong seven, tiger seven, Indian valerian, etc. It is a perennial herb, and its medicinal part is its rhizome. Distributed in Shaanxi, Henan, Hubei, Sichuan, Guizhou, Yunnan and other places. Now included in the "Pharmacopia of the People's Republic of China" (2010 edition). [0003] "Compendium of Materia Medica" records: "The fragrance of spiders comes from the mountains of Maosongfan in the west of Shu. The grass roots are also black with thick whiskers, shaped like spiders and Ligusticum ligusticum, and the smell is fragrant. [0004] Spider incense is r...

Claims

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Application Information

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IPC IPC(8): A61K36/84A61K47/69A61P31/04C11B9/02
Inventor 焦家良灵晓燕陈刚高瑾
Owner 云南龙发制药股份有限公司
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