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Method for preparing ZrO2 bone repair biological ceramic scaffold material through gradient dip-coating of HA

A technology of bioceramics and scaffold materials, applied in coating, tissue regeneration, medical science, etc., can solve the problems of excessive strength of dense bodies, stress shielding, etc., achieve firm osseointegration, increase contact surface area, and meet immediate stability Effect

Inactive Publication Date: 2017-08-18
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the excessive strength of the dense body also brings about the problem of stress shielding.

Method used

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  • Method for preparing ZrO2 bone repair biological ceramic scaffold material through gradient dip-coating of HA
  • Method for preparing ZrO2 bone repair biological ceramic scaffold material through gradient dip-coating of HA
  • Method for preparing ZrO2 bone repair biological ceramic scaffold material through gradient dip-coating of HA

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Experimental program
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Effect test

Embodiment 1

[0076] 1.1 Pretreatment of model organic foam materials

[0077] Polyurethane is used as the foam model material, because the polyurethane material has a network interlayer, and the existence of the interlayer makes it difficult for the slurry to enter the interior of the foam model, which will cause plugging, uneven distribution of the slurry, and poor porosity of the sintered foam ceramics. and poor mechanical properties. Therefore, it is necessary to open the membrane first, so that the organic foam forms a three-dimensional network structure. In addition, the organic foam model has poor hydrophilicity and small wetting angle, so the slurry is not easy to adsorb. In order to improve the slurrying performance of the foam model material, pretreatment is required. Cut the organic polyurethane foam material into a semi-cylindrical shape with a height of 24 cm and a radius of 9 cm, soak it in a 15 wt% sodium hydroxide solution at 60 °C for 3.5 h, rub it repeatedly with clean w...

Embodiment 2

[0086] 1.1 Animal model of femoral shaft defect

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Abstract

The invention relates to a preparation method of a biological ceramic scaffold material. The method for preparing the ZrO2 bone repair biological ceramic scaffold material through gradient dip-coating of HA comprises the following steps: (1) carrying out first-time dip-coating of slurry; and (2) carrying out second-time dip-coating of slurry, and carrying out cooling to obtain the bone repair biological ceramic scaffold material. Nanometer ZrO2 particles are added into HA, so that the compressive strength and the tenacity of the scaffold material are enhanced, and therefore, the bone repair biological ceramic scaffold with high porosity, large compressive strength and strong toughness is provided for bone defect treatment. The biological ceramic scaffold material has high porosity and suitable hole diameter, so that hydroxyapatite can be easily degraded and absorbed, the bone tissue can grow inwards easily, the fusing speed is high, the bonding with host bone is firm, the obvious foreign body reaction can not occur, the biocompatibility is good, and moreover, the biological ceramic can be used for bone tissue damage repair and also can be used for in-vitro cell culture.

Description

technical field [0001] The invention relates to a preparation method of a bioceramic support material. Background technique [0002] At present, it has become very common to treat patients with bone defects clinically by transplanting artificial bone. No matter what material the artificial bone comes from, the key to its successful transplantation is whether there is normal new bone tissue ingrowth in the grafted bone after surgery. It is mainly reflected in: 1. Whether sufficient amount of new bone is produced at the bone graft; 2. Whether there is a firm combination between the grafted bone and the normal bone tissue. It is worth noting that most of the bone grafts in clinical practice can only play the role of bone replacement, and cannot allow new bone to grow well into the graft and make it integrate. This also means that there is a risk of wear and aging of the grafted bone in the patient's body. Moreover, the healing of fractures after large-segment bone grafting i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/10A61L27/02A61L27/56
CPCA61L27/32A61L27/025A61L27/10A61L27/56A61L2430/02
Inventor 全仁夫王拓谢尚举
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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