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Antibacterial polyamino acid gel and preparation method thereof

A polyamino acid and gel technology, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of difficulty in large-scale application, complicated preparation methods and high production costs, and achieves suitable large-scale production. , the preparation method is simple, the effect of good antibacterial and biocompatibility

Inactive Publication Date: 2017-08-11
SUZHOU DOBIOM MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation method is complicated, its production cost is high, its large-scale application is difficult, and its antibacterial rate can only reach 90%.

Method used

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  • Antibacterial polyamino acid gel and preparation method thereof
  • Antibacterial polyamino acid gel and preparation method thereof
  • Antibacterial polyamino acid gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Composition of polyamino acid antibacterial gel:

[0045] Component weight ratio / % Polyamino acid50 Carbomer0.01 Edible sodium hydroxide0.004 glycerin2 Ethyl paraben0.2 purified water margin

[0046] Polyamino acid structure:

[0047] The preparation method of the polyamino acid antibacterial gel of the present invention includes the following steps:

[0048] (1) Dissolve polyamino acid in purified water;

[0049] (2) Disperse the carbomer in purified water to fully swell it, add edible sodium hydroxide, adjust the pH to 8, add glycerin and ethyl paraben to obtain a carbomer gel matrix;

[0050] (3) The polyamino acid solution obtained in step (1) is added to the carbomer gel matrix obtained in step (2) and mixed to prepare a polyamino acid antibacterial gel for external use in the treatment of gynecology.

[0051] The antibacterial gel obtained in this example was tested in accordance with the standard GB15979-2002 "Sanitary Standards for Disposable Sanitary Products". ...

Embodiment 2

[0054] Composition of polyamino acid antibacterial gel:

[0055] Component weight ratio / % Polyamino acid0.01 Carbomer7 Propylene Glycol0.1 Ethanol40 glycerin0.05 Ethyl Paraben1 Triethanolamine0.1 purified water margin

[0056] Polyamino acid structure:

[0057] The preparation method of the polyamino acid antibacterial gel of the present invention includes the following steps:

[0058] (1) Dissolve polyamino acid in purified water;

[0059] (2) Disperse carbomer in purified water to make it fully swell;

[0060] (3) Add ethyl paraben to ethanol, dissolve it, then add propylene glycol, glycerin, and triethanolamine, control the pH to 4, and mix;

[0061] (4) Add the solutions obtained in steps (1) and (3) to the solution obtained in step (2), and mix them to prepare a polyamino acid antibacterial gel for treating the anorectal area.

[0062] The antibacterial gel obtained in this example was tested for antibacterial performance according to the standard GB15979-2002 "Sanitary S...

Embodiment 3

[0065] Composition of polyamino acid antibacterial gel:

[0066] Component weight ratio / % Polyamino acid10 Carbomer1 Chitosan10 Methyl glycol chitosan10 Sodium Hydroxymethyl Cellulose4 glycerin8 sodium benzoate0.001 hydrochloric acid0.1 purified water margin

[0067] Polyamino acid structure:

[0068] The preparation method of the polyamino acid antibacterial gel of the present invention includes the following steps:

[0069] (1) Dissolve polyamino acid in purified water;

[0070] (2) Adjust the pH of the solution obtained in step (1) to 6.0 with 1 mol / L dilute hydrochloric acid, add chitosan and methyl glycol chitosan, and mix well to obtain a mixed solution;

[0071] (3) Carbopol, sodium hydroxymethyl cellulose, benzoic acid and glycerin are added to the mixed solution obtained in step (2), and mixed well to prepare a polyamino acid antibacterial gel for treating vaginitis.

[0072] The antibacterial gel obtained in this example was tested for antibacterial performance acc...

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Abstract

The invention discloses polyamino acid gel. The polyamino acid gel is prepared from the following components in percentage by weight: 0.01-50 percent of polyamino acid, 0.01-90 percent of gel matrix, 0-20 percent of humectant, 0-1 percent of preservative and the balance of water. The invention further discloses a method for preparing the polyamino acid antibacterial gel. The polyamino acid gel combines advantages of the polyamino acid material and gel, has excellent antibacterial property and biocompatibility, can be used in biomedical fields of diabetic skin infection, burns, scalds, bedsore infection, skin inflammation, oral infection, gynecological diseases or anorectal diseases and the like. The polyamino acid antibacterial gel has a bacteriostasis rate of more than or equal to 95 percent, which is far higher than that of similar products.

Description

Technical field [0001] The invention relates to an antibacterial gel and a preparation method thereof, in particular to an antibacterial polyamino acid gel and a preparation method thereof. Background technique [0002] At present, the gel is widely used to treat infectious parts such as surgical trauma, skin inflammation, gynecological inflammation, rectal inflammation, and chronic difficult-to-heal wounds. The antibacterial ingredients contained in many gel dressings or medicines have great side effects. Because of its protein-like structure, polyamino acid materials have the advantages of good biocompatibility and biodegradability, and have been widely used in biomedical fields such as controlled drug release, tissue engineering, and gene therapy. [0003] Chinese patent application CN105694030A discloses a hybrid antibacterial hydrogel compounded with oligomer acid and sodium alginate. But its preparation method is complicated, production cost is high, large-scale application...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/785A61P17/02A61P31/04A61P15/00A61P15/02A61P1/02A61P1/00A61P3/10
CPCA61K9/06A61K31/785A61K47/32
Inventor 牛之猛张善勇
Owner SUZHOU DOBIOM MEDICAL TECH CO LTD
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