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Compound anti-inflammation healthcare toothpaste with mango leaf extract and method for preparing compound anti-inflammation healthcare toothpaste

A technology of mango leaves and extracts, which is applied in dentistry, drug combinations, and pharmaceutical formulations, etc., can solve the problems of low bioavailability and unsatisfactory clinical trial results, and achieve the effect of improving oral inflammation

Active Publication Date: 2017-08-11
杭州怡辉跃康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the extremely low bioavailability of mangiferin to the human body, the clinical trials of these oral preparations are not ideal

Method used

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  • Compound anti-inflammation healthcare toothpaste with mango leaf extract and method for preparing compound anti-inflammation healthcare toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A. Raw material preparation: take fresh mango leaves as raw materials, dry them naturally or at 50°C, and crush them through a 20-mesh sieve.

[0038] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 3L of ethyl acetate, seal and soak for 5h, extract by shaking at room temperature for 15min, and filter; repeat extraction 4 times, the green color of the extract basically disappears.

[0039] C. Methanol extraction: Take the residue extracted in step B, add 2.5L of methanol, seal and soak at 30°C for 5h, stir and extract at 55°C for 0.5h, filter while hot, repeat extraction 5 times, combine the extracts, and precipitate at room temperature 9h, finely filter with a 200-mesh filter.

[0040] D. Concentration and washing: Concentrate the filtrate of step C by vacuum rotary evaporation at 50°C to obtain about 50g of concentrated extract, add 150mL of methanol, stir and wash at 55°C for 10min, let cool, filter with a 200-mesh filter, and wash rep...

Embodiment 2

[0042] A. Raw material preparation: take fresh mango leaves as raw materials, dry them in the sun, and crush them through a 30-mesh sieve.

[0043]B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 4L of ethyl acetate, seal and soak for 4h, shake at room temperature for 10min, filter; repeat extraction 3 times, the green color of the extract basically disappears.

[0044] C. Methanol extraction: Take the residue extracted in step B, add 4L of methanol, seal and soak at 40°C for 4h, stir and extract at 60°C for 0.5h, filter while hot, repeat the extraction 4 times, combine the extracts, and precipitate at room temperature for 10h , and finely filter with a 200-mesh filter.

[0045] D. Concentration and washing: Concentrate the filtrate of step C into a concentrated extract by vacuum rotary evaporation at 65°C, add 200mL of methanol, stir and wash at 50°C for 20min, let it cool, filter with a 200-mesh filter, and wash 5 times repeatedly. Yellow-whit...

Embodiment 3

[0047] A. Raw material preparation: take fresh mango leaves as raw material, dry at 65°C, and crush through a 40-mesh sieve.

[0048] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 2L of ethyl acetate, seal and soak for 6h, shake at room temperature for 20min, filter; repeat extraction 5 times, the green color of the extract basically disappears.

[0049] C. Methanol extraction: take the residue extracted in step B, add 2L of methanol, seal and soak at 30°C for 6h, stir and extract at 60°C for 1h, filter while hot, repeat the extraction 6 times, combine the extracts, and precipitate at room temperature for 12h. Finely filter with a 200-mesh filter.

[0050] D. Concentration and washing: Concentrate the filtrate of step C into a concentrated extract by vacuum rotary evaporation at 65°C, add 130mL of methanol, stir and wash at 50°C for 20min, let it cool, filter with a 200-mesh filter, and wash 5 times repeatedly. Yellow-white particles. The fi...

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Abstract

The invention belongs to the field of medical care and daily chemical products, and particularly relates to compound anti-inflammation healthcare toothpaste with mango leaf extract and a method for preparing the compound anti-inflammation healthcare toothpaste. The mango leaf extract is used as a main active anti-inflammation component of the compound anti-inflammation healthcare toothpaste. The compound anti-inflammation healthcare toothpaste comprises main active components including, by weight, 1-2 parts of mango leaf extract, 3-5 parts of salicylic acid and 8-12 parts of menthol. The content of mangiferin in the mango leaf extract is 60%-70%. The compound anti-inflammation healthcare toothpaste and the method have the advantages that excellent effects of preventing and treating oral inflammation such as oral ulcer and gingivitis can be realized by the compound anti-inflammation healthcare toothpaste; the mango leaf extract, the salicylic acid and the menthol are matched with corresponding auxiliary materials to obtain the compound anti-inflammation healthcare toothpaste, accordingly, daily oral cleaning requirements can be met, and obvious effects of improving the oral inflammation such as the oral ulcer and the gingivitis further can be realized by the compound anti-inflammation healthcare toothpaste.

Description

technical field [0001] The invention belongs to the field of medical care and daily chemical products, in particular to a compound mango leaf extract anti-inflammatory health care toothpaste with mango leaf extract as the main active anti-inflammatory component and a preparation method thereof. Background technique [0002] Mango (Mangifera indica L.) is a common tropical fruit in southern my country. The mango planting area in the Panxi region of Sichuan reaches more than 300,000 mu, featuring high yield and good quality, occupying the domestic late-maturing mango market, and the mango industry has become the leading industry in local agriculture. The long-term measurement and analysis by the inventor shows that the content of mangiferin (mangiferin) in mango leaves in Panxi area is as high as 2-8%, which is much higher than that in other plants such as Anemarrhena anemarrhena, and is also much higher than that in mango leaves in other production areas in my country. conten...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/60A61K8/46A61K8/368A61K8/365A61K8/36A61K8/34A61K8/24A61Q11/00A61K36/22A61P1/02A61K31/60A61K31/045
CPCA61K8/24A61K8/34A61K8/345A61K8/36A61K8/365A61K8/368A61K8/463A61K8/60A61K8/73A61K8/731A61K8/97A61K31/045A61K31/60A61K36/22A61K2800/524A61Q11/00A61K2300/00
Inventor 尚远宏韦会平韩洪波田金凤
Owner 杭州怡辉跃康科技有限公司
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