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A magnetic resonance/nuclear medicine dual-mode molecular imaging probe and its preparation method

A molecular imaging and nuclear medicine technology, applied in the field of magnetic resonance/nuclear medicine dual-modal molecular imaging probes, can solve the problems of easy detachment of surface ligand molecules and poor labeling stability, and achieve the effect of improving labeling stability

Active Publication Date: 2020-03-17
苏州欣影生物医药技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Objective: In order to overcome the deficiencies in the prior art, the present invention provides a magnetic resonance / nuclear The medical dual-modal molecular imaging probe, with magnetic nanoparticles as the core, innovatively introduces coordination metal ions on its surface, and uses the coordination between the coordination metal ions and the ligand molecules on the surface of the magnetic nanoparticles to cross-link the surface Ligand molecules, enhance the binding ability of surface ligand molecules and magnetic nanoparticles, thereby improving the labeling stability of radionuclides on magnetic nanoparticles; improve the radiolabeling stability of the resulting magnetic resonance / nuclear medicine dual-mode molecular imaging probe

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  • A magnetic resonance/nuclear medicine dual-mode molecular imaging probe and its preparation method
  • A magnetic resonance/nuclear medicine dual-mode molecular imaging probe and its preparation method
  • A magnetic resonance/nuclear medicine dual-mode molecular imaging probe and its preparation method

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Embodiment 1

[0041] This embodiment is a comparative test to verify the feasibility of the scheme of this patent.

[0042] According to the literature (Advanced Materials, 2014, 26, 2694-2698), oil-soluble magnetic iron oxide nanoparticles with an average particle size of 8nm were synthesized, and one end was bisphosphate group and the other end was phenolic hydroxyl group by ligand exchange. The polyethylene glycol 2000 was modified to the surface of magnetic iron oxide nanoparticles, and then configured into an aqueous solution of magnetic nanoparticles with an iron concentration of 1 mg / mL. The electron microscope photos and particle size distribution diagrams of the obtained water-soluble magnetic iron oxide nanoparticles are shown in figure 1 shown. Take 200uL of the above nanoparticle solution, add 20uL of ultrapure water, and after 30min, use the chloramine-T method to carry out radioactivity on the nanoparticles. 125 I labeling, the specific steps are as follows: 50uL of TB buffer...

Embodiment 2

[0044] According to the literature (Advanced Materials, 2014, 26, 2694-2698), oil-soluble magnetic iron oxide nanoparticles with an average particle size of 8nm were synthesized, and one end was bisphosphate group and the other end was phenolic hydroxyl group by ligand exchange. The polyethylene glycol 2000 was modified to the surface of magnetic iron oxide nanoparticles, and then configured into an aqueous solution of magnetic nanoparticles with an iron concentration of 1 mg / mL. The electron microscope photos and particle size distribution diagrams of the obtained water-soluble magnetic iron oxide nanoparticles are shown in figure 1 shown. Take 200uL of the above nanoparticle solution and add 20uL of GdCl with a Gd ion concentration of 1mg / mL 3 Aqueous solution, mix well and react for 30min. Radioactivity was then performed on the nanoparticles using the chloramine-T method 125 I labeling, the specific steps are as follows: in the above-mentioned magnetic nanoparticle aqueo...

Embodiment 3

[0047] According to the literature (Advanced Materials, 2014, 26, 2694-2698), oil-soluble magnetic iron oxide nanoparticles with an average particle size of 3.5 nm were synthesized, and one end was a bisphosphate group, and the other end was a formazan Oxygenated polyethylene glycol 5000 is modified to the surface of magnetic iron oxide nanoparticles, and then configured into an aqueous solution of magnetic nanoparticles containing iron at a concentration of 1 mg / mL. Take 200uL of the above-mentioned nanoparticle solution, and perform radioactivity on the nanoparticle by stannous chloride reduction method. 99m Tc labeling, the specific steps are as follows: Take 100uL of Na 99m TCO 4 solution (activity 2mCi), add 20uL 1mg / mL stannous chloride solution (configured with 0.1M hydrochloric acid), mix and react for 5min, then add the magnetic nanoparticle aqueous solution, mix evenly, and react at room temperature for 30min, It can be obtained by ultrafiltration and purification ...

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Abstract

The invention discloses a magnetic resonance / nuclear medicine bimodal molecular imaging probe and a preparing method thereof. By means of interaction between metal ions and magnetic nanoparticle surface ligand molecules, magnetic nanoparticle surface ligand molecules are crosslinked, so that the binding force between the surface ligand molecules and magnetic nanoparticles is improved, the mark stability of radionuclide on magnetic nanoparticles is improved, and the high-stability magnetic resonance / nuclear medicine bimodal molecular imaging probe is obtained. The preparing method is simple, the high-stability magnetic resonance / nuclear medicine bimodal molecular imaging probe can be obtained conveniently and quickly, and application prospects are broad.

Description

technical field [0001] The invention relates to a magnetic resonance / nuclear medicine dual-mode molecular imaging probe, in particular to utilizing the interaction between metal ions and ligand molecules on the surface of magnetic nanoparticles, cross-linking the ligand molecules on the surface of magnetic nanoparticles, and strengthening the ligand molecules on the surface The binding force with magnetic nanoparticles, and on this basis, a highly stable magnetic resonance / nuclear medicine dual-mode molecular imaging probe is obtained. Background technique [0002] Cancer is one of the important diseases that threaten human health, and its early diagnosis is one of the keys for human beings to overcome cancer. At present, magnetic resonance imaging and nuclear medicine imaging are important methods for clinical tumor diagnosis, but they all have their own advantages and disadvantages. For example, magnetic resonance imaging (MRI, Magnetic Resonance Imaging) is safe, non-inva...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/10A61K49/18A61K49/00A61K51/02A61K51/12A61P35/00B82Y30/00B82Y40/00A61K101/02A61K103/10A61K103/20A61K103/00A61K103/32
CPCA61K49/0002A61K49/101A61K49/1827A61K51/02A61K51/1244B82Y30/00B82Y40/00
Inventor 高振宇曾剑峰高明远
Owner 苏州欣影生物医药技术有限公司
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