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Composition containing astragalus polysaccharide and atractylodes oil, and preparation method and application thereof

A technology of astragalus polysaccharide and atractylodes stearin, which is applied in the field of medicine, can solve the problem of no synergistic anti-peptic ulcer effect of the composition, and achieve good synergistic effect and good curative effect

Inactive Publication Date: 2017-07-14
苏州半部堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, in the prior art, there is no report on the preparation of a pharmaceutical composition by mixing astragalus polysaccharides and atractylodes stearin, and there is no report that the composition can produce a synergistic anti-peptic ulcer effect

Method used

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  • Composition containing astragalus polysaccharide and atractylodes oil, and preparation method and application thereof
  • Composition containing astragalus polysaccharide and atractylodes oil, and preparation method and application thereof
  • Composition containing astragalus polysaccharide and atractylodes oil, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Get 1000 g of dry roots of Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao, soak in 95% (V / V) ethanol to degrease, centrifuge to remove ethanol, extract twice with 12L water at 90°C, combine water Concentrate the extract under reduced pressure until the total volume of the extract is about 8L, add 24L of 95% (V / V) ethanol, let stand overnight at 4°C, and centrifuge to obtain a precipitate;

[0042] Dissolve the obtained precipitate with 3L of pure water, centrifuge to remove insoluble matter, adjust the supernatant to pH 2.8 with 2N HCl, let it stand at 4°C for 4 hours, centrifuge to remove the precipitate, adjust the pH to 9 with 2N NaOH, add 90mL 30wt% h 2 0 2 After stirring and decolorizing at 60°C for 1 hour, add 9L of 95% (V / V) ethanol, stand overnight at 4°C, centrifuge to obtain a precipitate, wash the resulting precipitate twice with 2L of 90% ethanol, and dry under reduced pressure at room temperature to obtain Astragalus total polysaccharid...

Embodiment 2

[0047] Take 1000 g of dried roots of Astragalus membranaceus (Fisch.) Bge., soak in 95% (V / V) ethanol to degrease, centrifuge to remove ethanol, extract twice with 12L water at 90°C, combine the water extracts, and concentrate under reduced pressure to The total volume of the extract is about 8L, add 24L of 95% (V / V) ethanol, let stand overnight at 4°C, and centrifuge to obtain a precipitate;

[0048] Dissolve the obtained precipitate with 3L of pure water, centrifuge to remove insoluble matter, adjust the supernatant to pH 2.8 with 2N HCl, let it stand at 4°C for 4 hours, centrifuge to remove the precipitate, adjust the pH to 9 with 2N NaOH, add 90mL 30wt% h 2 0 2 After stirring and decolorizing at 60°C for 1 hour, add 9L of 95% (V / V) ethanol, stand overnight at 4°C, centrifuge to obtain a precipitate, wash the resulting precipitate twice with 2L of 90% ethanol, and dry under reduced pressure at room temperature to obtain Astragalus total polysaccharides;

[0049] The astr...

Embodiment 3

[0054] Atractylodes stearin extract prepared by steam distillation

[0055] Put 1kg of dry rhizome granules of Atractylodes atractylodis into the grinding bottle of the volatile oil extractor, continue distilling for 5 hours according to the method in the appendix of Chinese Pharmacopoeia, then stop heating, pour water after cooling, and collect the oil on the surface of the distillate, which is Atractylodes stearin extract .

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Abstract

The invention discloses a composition containing astragalus polysaccharide and atractylodes oil. The composition comprises an astragalus polysaccharide extract and a atractylodes oil extract, wherein the astragalus polysaccharide extract is a total polysaccharide extracted from dry roots of leguminous plant Mongolia astragaloside or Astragalus membranacus; saccharide content in the astragalus polysaccharide extract is not lower than 80wt percent of the total amount of extracts; the weight-average molecular weight of the polysaccharide is not lower than 20kD; the rhizoma atractylodis stearine extract is a total volatile oil extracted from dried rhizoma atractylodis; and the total content of atractylol and eudesmol is not lower than 50wt percent of the total amount of extracts. The invention also provides a preparation method and application of the composition. Under the synergistic effect of the two components of the composition provided by the invention, the treatment effect on peptic ulcers is improved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition containing astragalus polysaccharide and atractylodes stearin, a preparation method and application thereof. Background technique [0002] The medicinal use of Astragalus has a history of more than 2,000 years. The nature and flavor of Astragalus: sweet, slightly warm. It belongs to the lung, spleen, liver, and kidney meridians, and has the functions of enhancing the body's immune function, protecting the liver, diuresis, anti-aging, anti-stress, lowering blood pressure, and extensive antibacterial effects. However, it must be forbidden to take if there are excessive evils on the surface, stagnation of qi and dampness, stagnation of food accumulation, carbuncle and gangrene at the beginning or after ulceration, heat and toxin still prevailing, and those with yin deficiency and yang hyperactivity. [0003] The main function of Atractylodes Rhizoma A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P1/04A23L33/125A23L33/115
Inventor 纪旭
Owner 苏州半部堂生物科技有限公司
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