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Absorption promoter for improving bioavailability of polysaccharide medicines

A technology of absorption enhancers and polysaccharides, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of limited usage and restrictions on wide application, and achieve the goals of reducing dosage, reducing side effects, and significant application value Effect

Inactive Publication Date: 2017-07-14
高其品
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There have been some research reports on the work in this area. Most of the ingredients found to have a certain absorption-promoting effect on polysaccharides are different surfactants, but due to the limitation of their usage, their use has been limited to a certain extent. Wide application in practice

Method used

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  • Absorption promoter for improving bioavailability of polysaccharide medicines
  • Absorption promoter for improving bioavailability of polysaccharide medicines
  • Absorption promoter for improving bioavailability of polysaccharide medicines

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Embodiment Construction

[0015] The present invention will be further described in detail below in conjunction with specific embodiments, which is a further explanation of the content of the present invention, but does not mean that the present invention is limited thereto.

[0016] 1. Sample preparation

[0017] 1. Preparation of Anluo Xiaopi polysaccharide: Anluo Xiaopi extract (purchased from Hubei Xinkai Pharmaceutical Co., Ltd.) 5kg, add 6 times the amount of water, extract twice, each time for 1 hour, filter and combine The filtrate was concentrated, and ethanol was added to the concentrated solution until the ethanol content was 80%, the ethanol was recovered, and the precipitate was vacuum-dried to obtain the polysaccharide of Anluo parsley. The sugar content of this sample was 62.3%, the protein (peptide) content was 18.7%, and the water content was 7%.

[0018] 2. Preparation of tremella polysaccharide: Tremella extract (purchased from Hubei Xinkai Pharmaceutical Co., Ltd.) 5kg, add 10 time...

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Abstract

The invention discloses an absorption promoter for improving the bioavailability of tryptophan and other polysaccharide medicines. The absorption promoter of tryptophan, phenylalanine, baicalin, ginseng stem and leaf total saponins and other polysaccharide medicines is combined with tremella polysaccharides, Marasmius androsaceus polysaccharides and other polysaccharide medicines, so the gastrointestinal tract absorption and in-blood ability of the polysaccharide medicines is promoted, the bioavailability of polysaccharide medicines is improved, the problems of difficult oral absorption and low bioavailability of the polysaccharide medicines are solved, and the activity and the curative effects of the oral polysaccharide medicines are improved.

Description

technical field [0001] The invention relates to an absorption enhancer capable of improving the bioavailability of polysaccharide drugs. Specifically, it involves tryptophan, phenylalanine, baicalin, and total saponins of ginseng stems and leaves as absorption accelerators for polysaccharide drugs. Promote the ability of polysaccharide drugs to absorb into the blood through the gastrointestinal tract, and improve the bioavailability of polysaccharide drugs. The invention belongs to the technical field of traditional Chinese medicine. Background technique [0002] Polysaccharides are another important class of biological macromolecules besides proteins and nucleic acids in organisms. They have a variety of biological functions. They have almost no xenobiotic metabolism toxicity of small molecular compounds. They are relatively safe to use and interact with other drugs. The effect is relatively small. Because of its above-mentioned characteristics and good prospects for man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P1/00A61K31/405A61K31/198A61K31/7048A61K31/715
CPCA61K31/198A61K31/405A61K31/7048A61K31/715A61K36/258A61K2300/00
Inventor 高阳张洪鹤徐多多高其品
Owner 高其品
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