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Metal organic complex having antineoplastic activity

An anti-tumor activity, metal-organic technology, applied in the direction of anti-tumor drugs, organic active ingredients, medical preparations containing active ingredients, etc., to achieve good inhibitory effect and simple design effect

Inactive Publication Date: 2017-07-04
FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chemotherapy drugs such as cisplatin have serious adverse reactions such as nephrotoxicity, neurotoxicity, bone marrow suppression, etc. However, the use of such drugs still appears in the treatment plan of more than 50% of cancer patients

Method used

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  • Metal organic complex having antineoplastic activity
  • Metal organic complex having antineoplastic activity
  • Metal organic complex having antineoplastic activity

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Embodiment Construction

[0016] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0017] 2.05mmol 2,6-pyridinedicarboxylic acid and 1.2mmol Pr(NO 3 ) 3 •6H 2 O was dissolved in 5 mL of deionized water respectively, and 1.2 mmol of anhydrous piperazine was added respectively, and then the two solutions were mixed and put into a stainless steel reaction kettle lined with polytetrafluoroethylene, and reacted at a constant temperature of 120 ° C for 5 days, and then cooled naturally. Suction filtration and rinse with deionized water to obtain green transparent columnar crystals, which are metal coordination compounds [Pr(C 7 h 3 NO 4 ) 3 ]•C 4 h 10 N 2 , the yield is about 70% (calculated as Pr).

[0018] 1. [Pr(C 7 h 3 NO 4 ) 3 ]•C 4 h 10 N 2 Characterization of single crystals

[0019] a. ...

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Abstract

The invention discloses a metal organic complex having antineoplastic activity. A chemical reaction of the complex is [Pr(C7H3NO4)3].C4H10N2, the molecular weight is 1677.01, is characterized by comprising a zero-dimensional structure and a trigonal system, a space group is P-3, the unit cell parameter is a=14.953(2), b=14.953(2), c=10.099(2), alpha=beta=90 DEG, gamma=120 DEG, V=1955.5(5), Z=1; wherein the metal organic complex is prepared by taking Pr(NO3)3.6H2O, 2,6-dipicolinic acid, and anhydrous piperazine as raw materials through a hydrothermal method. The process is simple, cost is low, the obtained complex has good inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal cancer cell line OE-19, and is hopeful for preparing the corresponding antitumor drug.

Description

technical field [0001] The invention belongs to the field of preparation of coordination compounds, and in particular relates to a metal-organic complex with antitumor activity and its preparation method and application. Background technique [0002] Coordination compounds, referred to as complexes, usually refer to a class of highly regular infinite network structures formed by metal ions (central atoms) and adjacent ions or molecules (organic ligands) through coordination bonds. bit polymer. Due to the diversity of composition and the controllability of structure, the research content of the synthesis, properties, structure and bonding of coordination compounds is very rich. Organo-metal complexes not only combine the unique characteristics of both inorganic metal ions and organic ligands, but also exhibit more excellent and diverse properties than pure inorganic materials and pure organic supramolecular materials. In the past two or three decades, complexes have develop...

Claims

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Application Information

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IPC IPC(8): C07D213/79C07D213/803A61K31/555A61P35/00
CPCC07D213/79C07D213/803
Inventor 孙伟明康杰李祥辉郭林峰
Owner FUJIAN MEDICAL UNIV
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