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Dental restorative material and application thereof for promoting dentin remineralization

A technology for repairing materials and dentin, used in dentistry, dental prostheses, dental preparations, etc., can solve problems such as inapplicability to clinical needs, poor results, etc., to improve market competitiveness, solve the problem of mineral resources, and achieve a high degree of bionics. Effect

Active Publication Date: 2019-11-12
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a dental restorative material for promoting dentin remineralization and its application

Method used

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  • Dental restorative material and application thereof for promoting dentin remineralization
  • Dental restorative material and application thereof for promoting dentin remineralization
  • Dental restorative material and application thereof for promoting dentin remineralization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Preparation of the polypeptide solution: artificially synthesize a polypeptide whose amino acid sequence is EEEEEEEEEDSESSEEDR (ie, SEQ NO.1), and its structural formula is shown in Formula I. Disperse the peptide powder in distilled water and stir evenly to obtain a peptide solution with a concentration of 0.5 mg / ml.

[0068] Preparation of nano-amorphous calcium phosphate suspension: Purchase ACPN through commercial channels, such as the nano-powder of amorphous calcium phosphate produced by SIGMA-ALDRICH Co. LLC. The particle size is less than 150nm. Disperse the ACPN powder in distilled water and stir evenly to obtain an ACPN suspension with a concentration of 0.2 g / ml.

[0069] When using, apply the peptide solution on the surface of demineralized dentin for 1 minute, and then apply ACPN suspension for 2 minutes. Wherein, the usage amount of the polypeptide solution is 5ml, and the usage amount of the ACPN suspension is 5ml.

Embodiment 2 to 17

[0071] Except for the contents of Table 1 below, it was carried out in substantially the same manner as in Example 1.

[0072] Table 1 Raw materials and process parameters of dental restorative materials used to promote dentin remineralization

[0073] Example Peptide structure Peptide concentration (mg / ml) ACPN concentration (g / ml) Peptide application time (min) ACPN application time (min) 1 Formula Ⅰ 0.5 0.2 1 2 2 Formula Ⅰ 0.6 0.3 2 4 3 Formula Ⅰ 0.8 0.25 1 3 4 Formula II 0.1 0.25 1 3 5 Formula II 0.5 0.25 1 3 6 Formula II 0.6 0.25 1 3 7 Formula II 0.8 0.25 1 3 8 Formula II 1 0.25 1 3 9 Formula II 1.5 0.25 1 3 10 Formula II 0.6 0.2 1 2 11 Formula II 0.6 0.3 2 4 12 Formula II 0.6 0.1 1 3 13 Formula II 0.6 0.4 1 3 14 Formula II 0.6 0.25 0.5 3 15 Formula II 0.6 0.25 3 3 16 Formula II 0.6 0.25 1 1 1...

Embodiment 18-19

[0076] Proceed in substantially the same manner as in Example 6, except that PEG is added to the polypeptide solution. Specifically, a PEG solid with a molecular weight of 20,000 was dispersed in a system of water as a solvent to prepare a PEG hydrosol. Wherein, in order to ensure the viscosity of the hydrosol, the PEG contents added in Example 18 and Example 19 were 1 g / ml and 2 g / ml respectively. A magnetic stirrer and a shaker were used to mix the system evenly, and a PEG hydrogel with a stable state and a certain viscosity was obtained as the carrier of the polypeptide and ACPN.

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Abstract

The invention relates to a dental prosthetic material for promoting dentin remineralization. The dental prosthetic material for promoting dentin remineralization contains a polypeptide solution and a nanometer amorphous calcium phosphate suspension which are successively applied to the surface of a dentin surface, wherein the polypeptide solution and the nanometer amorphous calcium phosphate suspension are physically isolated before use; the polypeptide solution contains polypeptide and water, wherein the polypeptide has functions of adsorbing calcium ions and binding to type I collagen, and the polypeptide has a concentration of 0.5 to 0. 8 mg / ml; the nanometer amorphous calcium phosphate suspension contains nanometer amorphous calcium phosphate and water, wherein the concentration of nanometer amorphous calcium phosphate is 0.2 to 0.3 g / ml. The parental function polypeptide is combined with the nanometer amorphous calcium phosphate to be used, and the nanometer amorphous calcium phosphate can effectively realize the in situ remineralization on the dentin, with high degree of mineralization and bionic degree by setting the appropriate concentration ratio.

Description

technical field [0001] The invention relates to the field of dentistry, in particular to diseases in the field of dentistry that require remineralization after dentin tissue demineralization and improving the performance of existing resin materials. Background technique [0002] Common dental tissue diseases such as root caries, wedge-shaped defect, acid erosion, etc., as well as the durability reduction of dentin resin bonding strength in filling restorations all involve dentin demineralization and collagen fiber exposure. Early intervention to remineralize demineralized dentin such as root caries, wedge-shaped defects, and acid erosion through non-invasive treatment methods is considered to be an important means to prevent and prevent the further development of the disease. By remineralizing the exposed collagen fibers at the dentin-resin bond interface, it is thought that it may be possible to improve the durability of the dentin-resin bond interface. [0003] Fluorine p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/033A61K6/08A61K6/00A61K6/087A61K6/838A61K6/884A61K6/891
CPCA61K6/74A61K6/838A61K6/884A61K6/891C08L89/00C08L71/02
Inventor 田力丽钟波王秀梅王硕
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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