Traditional Chinese medicinal composition for treating nonalcoholic fatty liver diseases and preparation method of traditional Chinese medicinal composition

Abstract

The invention discloses a traditional Chinese medicinal composition for treating nonalcoholic fatty liver diseases and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from fructus aurantii, semen plantaginis, radix paeoniae rubra, endothelium corneum gigeriae galli, rhizoma curcumae longae, radix panacis quinquefolii, rhizoma anemarrhenae, radix astragali, rhizoma dioscoreae, radix remanniae, radix scrophulariae, radix glehniae, radix ophiopogonis, radix polygonati officinalis, rhizoma polygonati, radix trichosanthis, fructus corni, Chinese wolfberry fruits, glossy privet fruits, herba epimedii, moutan bark, poria cocos, radix aconiti carmichaeli, rhizoma alismatis, and fructus schisandrae. The preparation method comprises the following steps: taking the raw medicinal materials, carrying out uniform mixing, grinding the mixed raw medicinal materials into coarse powder, carrying out supercritical CO extraction, carrying out adsorption on the extracted liquid by adopting a macroporous adsorption resin, carrying out elution by adopting alcohol aqueous solution, filtering the eluant by adopting an ultrafiltration membrane, carrying out concentrating, and carrying out drying, thus obtaining the traditional Chinese medicinal composition. The traditional Chinese medicinal composition for treating nonalcoholic fatty liver diseases provided by the invention can prevent and treat fatty degeneration of the liver and protect the liver function, has the multi-target-point and multi-path treatment effects, and is free of toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating nonalcoholic fatty liver and a preparation method thereof. Background technique [0002] Fatty liver is liver fatty degeneration caused by various etiologies or diseases. When the lipid accumulation in the liver cells exceeds 5%, or when more than 1 / 3 of the liver cells per unit area undergoes fatty changes in histology, it is called fat liver. Fatty liver includes alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). Among them, non-alcoholic fatty liver disease is a clinicopathological syndrome characterized by steatosis, necrosis, inflammatory cell infiltration and fat accumulation in hepatic parenchymal cells without a history of excessive alcohol consumption. The disease spectrum includes non-alcoholic simple fatty liver (NAFL), non-alcoholic steatohepatit...

AI Technical Summary

Problems solved by technology

[0003] Modern medical drug treatment of non-alcoholic fatty liver mainly focuses on lowering lipids, protecting the liver and improving insulin resistance. Although the existing small-sample studies have found that it is indeed effective in improving objective indicators, there are still some shortcomings (such as: Although the use of lipid-lowering drugs can lower blood lipids, they cannot remove the fat deposited in the liver well, and long-term high-dose use of these drugs is prone to liver toxicity), and sometimes the effect of drug treatment does not match the improvement of the patient's own symptoms