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Anti-tartar toothpaste and preparation method thereof

An anti-tartar toothpaste and gelatin technology, applied in the field of oral care, can solve the problems of poor stability of peroxides, poor taste of toothpaste, corrosion of tooth enamel, etc., achieve the best suspension, reduce adsorption, and promote remineralization effects

Inactive Publication Date: 2017-06-09
缪来耿 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of the above-mentioned abrasives will cause certain damage and wear to the teeth of the user, and will also make the mouthfeel of the toothpaste worse. Especially, the crystal particle ultrastructure of calcium carbonate has more acute angles on the glazed surface of the teeth. Scratch; and the poor stability of peroxide limits its use; acid and alkali components will corrode tooth enamel

Method used

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  • Anti-tartar toothpaste and preparation method thereof
  • Anti-tartar toothpaste and preparation method thereof
  • Anti-tartar toothpaste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Embodiment 1 The preparation of intercalation and RGD polypeptide-gelatin nanoparticles

[0036]

[0037] Preparation of group A embedding and RGD polypeptide-gelatin nanoparticles:

[0038] (1) Weigh 200mg gelatin and dissolve it in 100mL water to make a gelatin solution with a concentration of 2mg / mL; weigh 100mg RGD polypeptide and dissolve it in 100mL water to make a concentration of 1mg / mL RGD polypeptide solution;

[0039] (2) Pass the gelatin solution and the RGD polypeptide solution prepared in step (1) through a 0.22 μm filter respectively, and set aside;

[0040] (3) Slowly add 3mg sulforaphane dropwise to 100mL gelatin solution, magnetically stir for 10min, then dropwise add sodium tripolyphosphate solution, the final concentration of described sodium tripolyphosphate in the solution is 4% (m / v), Continue magnetic stirring for 15 minutes, finally add 100 mL of RGD polypeptide solution, vortex for 8 minutes, centrifuge the liquid at 20,000 rpm for 30 minute...

Embodiment 2

[0042] The preparation of embodiment 2 amorphous calcium phosphate microspheres

[0043]

[0044] Preparation of group A amorphous calcium phosphate microspheres:

[0045] (1) Dissolve calcium chloride in water to make an aqueous calcium chloride solution, then add isooctyl ether phosphate to the calcium chloride aqueous solution, stir until the material is completely dissolved, and the isooctyl ether phosphate and chloride The molar ratio of calcium is 0.05:1;

[0046] (2) Dissolve sodium phosphate in water to make an aqueous solution of sodium phosphate, then add dropwise to the solution prepared in step (1), the mol ratio of the sodium phosphate to calcium chloride is 0.6:1, stir evenly, and then Add polylactic acid with a final concentration of 8% (m / v), conduct a microwave-assisted hydrothermal reaction at 100°C for 45 minutes, cool to room temperature, and centrifuge to collect the precipitate;

[0047] (3) The precipitate obtained in step (2) was washed 3 times wit...

Embodiment 3-6

[0050] The preparation of embodiment 3-6 antitartar toothpaste

[0051] The intercalated RGD polypeptide-gelatin nanoparticles in the anti-tartar toothpaste raw materials of Examples 3-6 of the present invention were obtained from Group A of Example 1; the amorphous calcium phosphate microspheres were prepared from Group D of Example 2. The composition and content thereof of each embodiment anti-tartar are shown in the table below:

[0052]

[0053]

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Abstract

The invention relates to anti-tartar toothpaste and a preparation method thereof. The toothpaste is prepared from the following components in parts by mass: 2 to 6 parts of tetrapotassium pyrophosphate, 15 to 30 parts of nested RGD polypeptide-gelatin nanparticles, 1 to 4 parts of polymethylacrylic acid 2-hydroxyl ethyl ester, 10 to 25 parts of amorphous calcium phosphate microspheres, 1 to 4 parts of lipoic acid, 1 to 4 parts of a surfactant, 1 to 3 parts of distannous citrate and 60 to 80 parts of a matrix. The toothpaste provided by the invention is extremely high in cleaning capacity for the oral cavity, is high in friction property and safety, can effectively clear tartars and whiten teeth, cannot injure the teeth and destroy enamels, and has a certain defense effect on decayed teeth and the tartars; furthermore, the toothpaste is uniform in texture, has a delicate taste, and is rich in foam and stable in property; even if the toothpaste body of the toothpaste is placed for a long time, no water appearance caused by layering is caused; if people use the toothpaste for a long time, a healthy oral cavity environment can be effectively retained, and the teeth can be protected.

Description

technical field [0001] The invention belongs to the field of oral care, and in particular relates to an anti-tartar toothpaste and a preparation method thereof. Background technique [0002] Tartar, also known as dental plaque, is a biofilm that gradually deposits on the surface of the teeth, consisting of food residues, exfoliated oral epithelial cells, saliva and bacteria. Generally, the texture of tartar is relatively soft and can be effectively removed by toothbrush and toothpaste. However, after long-term deposition of tartar combines with minerals in saliva, it will calcify and form hard tartar. Removal by general means requires scraping with specific instruments, which is very harmful to teeth. [0003] The formation of tartar not only affects the appearance of teeth, but also easily induces symptoms such as periodontitis and gingivitis, which brings pain to people. Therefore, the inhibition of tartar formation as well as effective removal of tartar is highly desira...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/65A61K8/64A61K8/46A61K8/02A61K8/23A61K8/24A61K8/55A61K8/58A61K8/81A61Q11/00A61P1/02
CPCA61K8/65A61K8/0245A61K8/0279A61K8/23A61K8/24A61K8/46A61K8/55A61K8/58A61K8/64A61K8/8152A61K2800/28A61K2800/413A61K2800/652A61Q11/00
Inventor 缪来耿
Owner 缪来耿
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