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Biflavone-copper complex and preparation method and application thereof

A technology of copper complexes and biflavones, which is applied in the field of bisflavone-copper complexes and their preparation, can solve the problems of no reports on the synthetic biological activity of bisflavone complexes

Inactive Publication Date: 2017-05-31
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, so far, the research on the synthesis and biological activity of biflavone complexes has not been reported

Method used

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  • Biflavone-copper complex and preparation method and application thereof
  • Biflavone-copper complex and preparation method and application thereof
  • Biflavone-copper complex and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of ethanol, accurately weigh 12.1mg of copper nitrate trihydrate, dissolve it with 5mL of ethanol, add the copper nitrate solution to the Ame solution dropwise, and add ethanol dropwise to the reaction solution -Ammonia water (V / V, 3:1) solution, adjust the pH to 6, keep at 30°C for 4-5h, precipitate, filter, wash with ethanol and water in turn, recrystallize in DMSO, and freeze-dry to obtain the Ame-Cu complex .

Embodiment 2

[0041] Accurately weigh 53.8 mg of Ame in a round bottom flask, dissolve it with 5 mL of 90% ethanol, accurately weigh 12.1 mg of copper nitrate trihydrate, dissolve it with 5 mL of 90% ethanol, add the copper nitrate solution dropwise to the Ame solution, add to the reaction solution Add ethanol-sodium ethoxide solution dropwise, adjust the pH to 5, keep at 30°C for 4-5h, precipitate, filter, wash with ethanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Cu complex.

Embodiment 3

[0043] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of methanol, accurately weigh 12.1mg of copper nitrate trihydrate, dissolve it with 5mL of methanol, add the copper nitrate solution dropwise to the Ame solution, and add methanol dropwise to the reaction solution - Sodium methoxide solution, adjust the pH to 7, keep at 40°C for 3-4h, precipitate occurs, filter, wash with methanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Cu complex.

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Abstract

The invention discloses a biflavone-copper complex and a preparation method and application thereof. The preparation method comprises the following steps of using the biflavone of amentotaxus as a ligand, using copper ions as center ions, and reacting, so as to obtain an amentotaxus biflavone-copper complex; featuring the structure of the complex by ultraviolet-visible light absorbing spectrum and high-resolution mass spectrum. At the same time, the anti-tumor and anti-oxidizing activities of the amentotaxus biflavone-copper complex are studied. After proofing by an MTT (3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide) method, the anti-tumor activity of the amentotaxus biflavone-copper complex is better than the anti-tumor activity of the amentotaxus biflavone; after proofing by a pyrogallol self-oxidizing method and an ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) method, the anti-oxidizing activity is better than the anti-oxidizing activity of the amentotaxus biflavone self. The biflavone-copper complex has the advantages that after forming, the anti-tumor activity and anti-cancer activity of the amentotaxus biflavone are improved, and the amentotaxus biflavone-copper complex may be used for developing medicines.

Description

technical field [0001] The invention belongs to the fields of organic synthesis and medicine, and specifically relates to a biflavone-copper complex and its preparation method and application. Background technique [0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Among them, Amentoflavone (Amentoflavone, Ame) is a relatively common type of amentoflavone compounds, and its structural formula is as follows: [0003] [0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome proliferator-activat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61P35/00A61P39/06
CPCC07F1/005A61P35/00A61P39/06
Inventor 徐莉杨世龙曹福亮卢雯唐颖周梦怡薛华玉
Owner NANJING FORESTRY UNIV
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