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A kind of method using octreotide acetate as template to prepare cubic silver nano box

An octreotide acetate and silver nanotechnology, applied in the field of materials, can solve the problems of high cost, potential environmental and biological hazards, complex preparation process, etc., and achieve the effects of regular morphology, good binding condition and simple preparation process

Active Publication Date: 2018-09-04
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have disadvantages such as complicated preparation process and high cost, and most of these synthetic methods use toxic reagents, which are potentially harmful to the environment and biology. development trend

Method used

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  • A kind of method using octreotide acetate as template to prepare cubic silver nano box
  • A kind of method using octreotide acetate as template to prepare cubic silver nano box
  • A kind of method using octreotide acetate as template to prepare cubic silver nano box

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare octreotide acetate solution with a concentration of 0.1mM and a pH value of 3, and then place it in a constant temperature metal bath at 60°C 30min;

[0023] Prepare AgNO at a concentration of 0.9mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 3%, they were mixed with a volume ratio of 1:1, and ultrasonic treatment was performed for 30 s, and the ultrasonic power was 90W, to obtain silver colloidal solution;

[0024] Prepare AgNO at a concentration of 7mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:3, placed in a digital display double-layer air bath constant temperature oscillator, at 200rpm, 15 Incubate at...

Embodiment 2

[0028] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare an octreotide acetate solution with a concentration of 0.2mM and a pH value of 2, and then place it in a constant temperature metal bath at 70°C 20min;

[0029] Prepare AgNO at a concentration of 1.1mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 2%, mixed with a volume ratio of 1:2, ultrasonically treated for 45s, and the ultrasonic power was 70W. Obtain silver colloidal solution;

[0030] Prepare AgNO at a concentration of 6mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:2, placed in a digital display double-layer air bath constant temperature oscillator, at 150rpm, 20 Incubate at ℃ for 30h;

[0031] Prepa...

Embodiment 3

[0034] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare an octreotide acetate solution with a concentration of 0.3mM and a pH value of 1, and place it in a constant temperature metal bath at 90°C for 10 minutes ;

[0035] Prepare AgNO at a concentration of 1.2mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 1% were mixed at a volume ratio of 1:3, and ultrasonic treatment was performed for 1 min, and the ultrasonic power was 60W. Obtain silver colloidal solution;

[0036] Prepare AgNO at a concentration of 4mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:1, placed in a digital display double-layer air bath constant temperature oscillator, at 100rpm, 30 Incubate at ℃...

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Abstract

A method for preparing cube-shaped silver nanoboxes using octreotide acetate as a template, which mainly uses octreotide acetate acid solution with a concentration of 0.1 to 0.3mM, and treats at a constant temperature of 60 to 90°C for 10 to 30 minutes; 1 to 3% ascorbic acid and Mix 0.9-1.2mM silver nitrate solution, 60-90W ultrasound for 30s-1min to obtain a silver colloidal solution; mix the above-mentioned octreotide acetate solution, silver colloidal solution and silver nitrate solution in a volume ratio of 1:1:1-3, Place in a shaker, incubate at 15-25°C for 20-50h; add dropwise sodium borohydride aqueous solution with a molar ratio of 8-12:1 to silver nitrate, react at 20-30°C until the color of the solution turns gray-black, and obtain Cubic silver nanoboxes. The invention has the advantages of simple preparation process, mild conditions, low cost, controllable shape and high metal loading rate, and can induce thermal fusion death of tumor cells through photothermal conversion under near-infrared light irradiation, thereby achieving the effect of treating tumors.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a preparation method of nanometer materials. Background technique [0002] Because silver nanomaterials have excellent catalytic, conductive, heat exchange and other properties, they have been widely used in antibacterial materials, catalytic materials, medical materials, etc. Therefore, the research on the preparation methods and characteristics of silver nanomaterials is particularly important. Studies have shown that the properties of metallic nanomaterials mainly depend on their size, morphology, composition, and crystallinity. In principle, the properties of metal nanomaterials can be tuned by controlling these parameters. Among these parameters, morphology control can be considered to provide one of the most efficient ways to tune the properties of metallic nanostructures. [0003] At present, the synthesis methods of nano-silver mainly include chemical reduction method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/0549B22F1/07B22F1/054
Inventor 高大威边可新高发明尹甜牛康刘欢李彦集
Owner YANSHAN UNIV
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