Guaifenesin and Dextromethorphan sustained release tablets and preparation method thereof

Abstract

The invention discloses Guaifenesin and Dextromethorphan sustained release tablets and a preparation method thereof. The Guaifenesin and Dextromethorphan sustained release tablets are composed of dextromethorphan hydrobromide and guaifenesin. The guaifenesin is a phlegm-expelling agent, and is capable of reflexively promoting increase of respiratory tract gland secretion by stimulating gastric mucosa to cause slight nausea, phlegm is diluted and coughed up; dextromethorphan hydrobromide is a central antitussive agent, has detect effect on coughing center of medulla oblongata, can inhibit cough reaction, and generates no addition. The Guaifenesin and Dextromethorphan sustained release tablets are used for treating cough and expectoration due to upper respiratory infection and bronchitis; compared with various same kinds of the product, the Guaifenesin and Dextromethorphan sustained release tablets have dual efficacies of eliminating phlegm and relieving cough, has the advantages of definite therapeutic effect, stable quality, and convenient administration, and is an ideal selection for medicine capable of relieving cough and resolving phlegm.

Description

technical field [0001] The present invention relates to the field of chemical drug sustained-release preparations, especially A sort of Yumei sustained-release tablet and its preparation method. Background technique [0002] Yumei Sustained-release Tablets are sustained-release preparations, the main components of which are dextromethorphan hydrobromide and guaiacol. This product is composed of the non-addictive antitussive drug dextromethorphan hydrobromide and the expectorant drug guaiacol. Dextromethorphan hydrobromide is a non-dependent central antitussive drug, which directly inhibits the medulla cough center and exerts an antitussive effect. It is an antitussive drug designated by the World Health Organization to replace codeine. It directly acts on medulla cough The central nervous system suppresses the cough response, is non-addictive, does not inhibit breathing, and has no drug resistance. Guaifenesin is a nauseous expectorant, which can stimulate the gastr...

AI Technical Summary

Problems solved by technology

However, the half-life of guaiacol is short, and it needs to be taken 3 to 4 times a day, which brings great inconvenience to patients. Patients often fail to take the medicine on time or even miss it, which affects the curative effect.