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A biodegradable phosphorus-magnesium whisker medical material capable of inhibiting the growth of cancer cells

A cancer cell, phosphorus and magnesium technology, applied in the field of medicine, can solve problems that have not been reported

Active Publication Date: 2020-10-02
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a degradable whisker material, there is no report on cell biology, especially on the inhibition of tumor cell growth.

Method used

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  • A biodegradable phosphorus-magnesium whisker medical material capable of inhibiting the growth of cancer cells
  • A biodegradable phosphorus-magnesium whisker medical material capable of inhibiting the growth of cancer cells
  • A biodegradable phosphorus-magnesium whisker medical material capable of inhibiting the growth of cancer cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Choose pure magnesium ≥ 99.9% material, its shape can be rod, block, strip, wire, powder (the particle size of powder ≥ 0.5mm), soak in one of the salts containing phosphate, hydrogen phosphate, dihydrogen phosphate or more, and one or more of chloride ion salts, carbonates, bicarbonates, and sulfates are blended in a stable mixed solution formed.

[0022] Example 1: Put a pure magnesium rod with a diameter of 3 mm and a length of 10 mm into a clean test tube, prepare 100 ml of soaking solution, which contains 9.8 grams of NaCl, 0.1 grams of KCl, and 0.15 grams of K 2 HPO 4 , 4.2 g Na 2 HPO 4 12H 2 O, 1.6 g MgSO 4 Then use a clean pipette to draw 10ml of the soaking solution and put it into a test tube of a magnesium rod. The temperature is set at 60°C. After a series of chemical corrosion observations, the time is 5 hours, and flocculent substances will be formed.

[0023] Example 2: Put a pure magnesium strip with a length of 10mm, a width of 5mm, and a thickness...

Embodiment 2

[0027] Weigh 3.0 mg, 5.2 mg, and 7.4 mg of the whisker fiber powder obtained in Example 1 with a precision balance, and put them into three clean test tubes with a volume of 5 ml. Then prepare 500ml of biological simulated body fluid Hanks, pH 7.4 solution for later use. Measure 3ml of the solution with a pipette and pour it into three test tubes containing the whisker fiber powder. After the preparation, the three test tubes were slightly shaken respectively, and stopped after one minute. The whisker fiber-containing powder was evenly suspended in the solution, and then stood still. The degradation changes of the whisker fiber solution were observed for 7, 24, 48, and 72 hours. It was found that the whisker fiber powder could be degraded in the simulated body fluid Hanks, and the pH value of the solution was detected. When testing, shake the test tube slightly for half a minute to make it into a uniform solution, and then measure. It was found that when the whisker fiber p...

Embodiment 3

[0030] 1. MTS cell proliferation and toxicity detection principle

[0031]MTS Cell Proliferation and Toxicity Detection Kit is a new water-soluble formazan compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethylcarboxylate)-2-(4 -sulfophenyl)-2H-tetrazole (Goldon), inner salt; MTS] is a colorimetric detection product for rapid and high-sensitivity detection of cell proliferation and cytotoxicity.

[0032] MTS is bioreduced by cells into a formazan compound soluble in tissue culture medium, and dehydrogenases in metabolically active living cells convert MTS into a liquid soluble formazan compound, which absorbs at 490nm Values ​​can be measured directly on 96-well plates without additional processing. The amount of formazan product represented by the absorbance measured at 490 nm is directly proportional to the number of viable cells in the culture. The more and faster the cell proliferation, the darker the color; the greater the cytotoxicity, the lighter the color. For th...

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Abstract

The invention aims at providing a novel degradable phosphorus-magnesium crystal whisker medical material with a cancer cell growth restraining effect. The phosphorus-magnesium crystal whisker medical material is characterized by being a magnesium salt compound with main component elements of phosphorus, magnesium and oxygen; the phosphorus, magnesium and oxygen content is larger than 60wt%, morphology of the material is columnar-shaped or flaky-shaped fluffy powder, the diameter is smaller than 50mu m, the length is larger than 100mu m, and the ratio of length to diameter is larger than 10 times. The degradable phosphorus-magnesium crystal whisker medical material is in a solid fluffy fiber shape and can change a pH value of a cancer cell growth microenvironment to restrain cancer cell growth in degrading. When crystal whisker fiber is prepared into liquid or is mixed with other solution to be prepared into liquid, an effect of restraining cancer cell growth is also achieved. By means of the effect of the crystal whisker material, the crystal whisker material can serve as a medical material for restraining cancer cells.

Description

technical field [0001] The invention relates to the field of medicine, and in particular provides a degradable phosphorus-magnesium whisker medical material capable of inhibiting the growth of tumor cancer cells. Background technique [0002] The technology of inhibiting the growth of cancer cells is a research hotspot in the field of medicine today. Tumor cancer cells are already the second largest cause of harm to people's health and life. People are stepping up research on how to inhibit the growth of cancer cells, such as gene therapy, molecular cell therapy, local chemotherapy, radiotherapy, etc. currently being studied. The results of these studies Breakthroughs are inseparable from the cooperation of new drugs. [0003] Due to the unique properties of whisker fiber materials, it has also attracted great attention from researchers in the medical field. People have carried out targeted medical research by using its physical and chemical structural characteristics. For ...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61P35/00
Inventor 肖克沈王贵学王华芹任伊宾陈佳周添杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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