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A nanotube-based fluorescent labeling carrier and its preparation method

A fluorescent labeling and nanotube technology, which is applied in fluorescence/phosphorescence, material analysis by optical means, material excitation analysis, etc., can solve the problems of difficult to precisely control the size of nanotubes, difficult to prepare nanotubes, and non-adjustable emission wavelength. , to achieve the effect of stable photochemical properties, ensuring high-efficiency radiation recombination, and no wavelength tailing

Active Publication Date: 2019-04-02
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Existing nanotubes are mainly obtained by chemical synthesis methods, and the size (diameter, length and wall thickness) of nanotubes is difficult to precisely control
In addition, due to the limitations of materials and structures, existing nanotube materials have technical bottlenecks such as non-luminescence, low luminous efficiency, or non-adjustable luminous wavelength.
The above technical difficulties make it difficult to prepare nanotubes for specific wavelengths and specific sizes

Method used

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  • A nanotube-based fluorescent labeling carrier and its preparation method
  • A nanotube-based fluorescent labeling carrier and its preparation method
  • A nanotube-based fluorescent labeling carrier and its preparation method

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Embodiment

[0045] Such as figure 1 As shown, the nanotube-based fluorescent labeling carrier of this embodiment includes: nanotube inner wall 31, quantum structure 4 and nanotube outer wall 32, nanotube inner wall 31 and nanotube outer wall 32 together constitute nanotube wall 3; Growing nanowires 2 upright on substrate 1; growing nanotube inner walls 31 outside the nanowires to wrap the side walls and tops of nanowires 2; growing quantum structures 4 on top of nanotube inner walls 31; growing nanotube inner walls 31 on the side walls and The nanotube outer wall 32 grows on the top of the quantum structure 4 , and the nanotube outer wall 32 wraps the side wall of the nanotube inner wall 31 and the top of the quantum structure 4 to form a core-shell structure.

[0046] Such as figure 2 As shown, the core-shell structure is transferred from the growth substrate 1 to the high-temperature-resistant substrate 6. After high-temperature annealing treatment, the nanowires 2 inside the core-she...

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Abstract

The invention discloses a nanotube-based fluorescence marked carrier and a preparation method thereof. The fluorescence marked carrier comprises a nanotube inner wall, a quantum structure and a nanotube outer wall. The size of the nanotube structure is designed according to the characteristics of a simulated carrying object, and the size of the nanotube structure is regulated and controlled accurately by controlling the growth condition; in the fixed-temperature annealing process, a nanowire in a core-shell structure is guaranteed to be decomposed completely and the quantum structure limited between the nanotube inner wall and the nanotube outer wall is not damaged; the fluorescence marked part of the nanotube adopts a semiconductor quantum structure, has high fluorescence intensity, long duration time and stable photochemical property, is insusceptible to photobleaching and realizes high-efficiency radiative recombination; furthermore, continuous broad spectrum excitation can be adopted, the absorption coefficient is big, fluorescence emission peak is narrow, wavelength trailing is avoided, and the distinguishing degree is high; the nanotube structure can realize fluorescence marked carrying of the carrying object in the tube and also can perform the traditional wrapping or combined type fluorescence marked carrying.

Description

technical field [0001] The invention relates to a method for preparing a fluorescent labeling carrier, in particular to a method for preparing a nanotube-based fluorescent labeling carrier. Background technique [0002] Fluorescent labeling technology originated in the 1940s and was first used to label antibodies to detect corresponding antigens. With the advancement of science and technology and the development of biomedicine, materials science and other fields, targeted detection and targeted therapy at the cell scale or molecular and atomic scales have become a major issue in many disciplines and fields such as medicine, biology, chemistry and materials science. As one of the research goals of the research, the labelable and non-destructive delivery of drugs and reagents is a key issue for the realization of precision medicine and precise detection. The traditional fluorescent labeling method mainly uses chemical reagents that have fluorescent properties or can produce f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6428G01N2021/6439
Inventor 王平王新强孙萧萧盛博文李沫张健沈波
Owner PEKING UNIV
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