Application of polypeptides to preparation of medicine for treating eczematous dermatitis

Abstract

The invention discloses application of polypeptides to preparation of a medicine for treating eczematous dermatitis and belongs to the field of treatment of eczematous dermatitis. The invention further provides a pharmaceutical composition for treating the eczematous dermatitis. The pharmaceutical composition is prepared from an effective dose of polypeptides as an active ingredient and pharmaceutically acceptable auxiliary materials or auxiliary ingredients into a preparation. Compared with the prior art, the polypeptide preparation has the advantages of remarkable effectiveness in treatment of the eczematous dermatitis, high safety and no side effect of hormones and is suitable for treatment of eczematous dermatitis patients at all ages.

Description

technical field [0001] The invention relates to the field of dermatitis and eczema treatment, in particular to the use of a polypeptide in the preparation of medicines for treating dermatitis and eczema. Background technique [0002] Dermatitis and eczema is a common disease in dermatology. Its clinical manifestations are characterized by symmetrical distribution of rashes, diversity, severe itching and recurrent attacks, and easy to evolve into chronic diseases. The disease can occur at any age, in any part, and in any season. Accounting for about 30% of skin secondary infections, dermatitis eczema occurs in infants, and the incidence rate in infants is about 35.28% (Liu Jie et al. Epidemiological investigation of infantile eczema pathogenesis [J]. China Maternal and Child Health, 2008, 23(21):3025-3026.). [0003] The etiology of dermatitis eczema is complex, including internal and external factors, the two are interrelated and synergistic. The internal causes are mainly...

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Problems solved by technology

Therefore, from carcinogenic and other perspectives, the use of calcineurin inhibitors appears to be problematic; 3. antihistamines, antihistamines can antagonize histamine, can play the role of antipruritic and antiallergic, benzene The first-generation antihistamines such as diphenhydramine, chlorpheniramine, and promethazine have a strong central nervous system depressant effect, and the use of the second-generation antihistamines has been gradually reduced due to the discovery of obvious cardiotoxicity (such as tefe Nadin, astemizole, etc.) (Shen Lifang et al., Action characteristics and application of several antihistamines, Chinese and foreign medical treatment, 2009 (7): 176.) 4. External antibiotics, when dermatitis eczema occurs, skin damage is easy Lead to infection, and children are easy to scratch the damaged part due to itching, which is more likely to lead to bacterial invasion

Topical antibiotics can control infection and prevent bacterial invasion, but antibiotics are prone to drug resistance

5. Others, such as zinc oxide, traditional Chinese medicine, etc. Zinc oxide ointment for external use is safe and effective, and is widely used, but it is slow in healing and wound recovery, and it is easy to cause infection; Traditional Chinese medicine such as Tongzhi has good curative effect on dermatitis and eczema, but it is time-consuming and slow to take effect

[0007] The applicant discovered the polypeptide of the present invention in research, which is an antimicrobial peptide, and has applied for a number of patents on its antimicrobial and other properties before. The prior art only reports the antibacterial performance of the polypeptide, and no See its report on treating dermatitis and eczema

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