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Triangle optimization method for separating target object in complex object by using simulated moving bed chromatography

A technology for simulating moving bed and chromatographic separation, applied in the field of triangle optimization to achieve the effect of simplifying the optimization process

Active Publication Date: 2017-04-26
UNIV OF SCI & TECH LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a triangular optimization method for the separation of complex mixtures with simulated moving bed chromatography for the deficiencies in optimization techniques when complex mixtures are separated by existing SMB chromatography

Method used

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  • Triangle optimization method for separating target object in complex object by using simulated moving bed chromatography
  • Triangle optimization method for separating target object in complex object by using simulated moving bed chromatography
  • Triangle optimization method for separating target object in complex object by using simulated moving bed chromatography

Examples

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Embodiment

[0061] A Triangular Optimization Method for the Separation of Rebaudioside A (RA) from Stevia Rebaudiana Extract by SMB Chromatography.

[0062] The SMB chromatographic system used: working mode: 1-1-2, I band is independent; 4 chromatographic columns, the chromatographic column specification is D×L=10mm×100mm; stationary phase: C18, 40-60 μm; mobile phase: ethanol-water , ratio 1:1; chromatographic separation temperature: room temperature.

[0063] HPLC detection conditions: analytical column: 4.6mm * 250mm (C18, 5 μm, Agilent, U.S.A.), mobile phase: the ratio of chromatographic acetonitrile and sodium dihydrogen phosphate buffer solution of pH=2.6 is 32 / 68 (v / v), flow velocity 1.0ml / min, measurement wavelength 213nm, measurement temperature 30°C.

[0064] The optimization method includes the following steps:

[0065] (1) prepare sample liquid by the proportioning of mobile phase ethanol and water of SMB chromatography, measure the concentration C of RA in sample liquid wit...

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Abstract

The invention discloses a triangle optimization method for separating a target object in a complex object by using a simulated moving bed chromatography, which belongs to the technical field of chromatography. The method comprises the following steps: determining a interfering component of the target object in a SMB separation system, endowing the concentration of the interfering component, then establishing a single column ideal chromatogram model, obtaining adsorption isotherm of the target object and the interfering component of a SMB separation unit, which is closer to the chromatogram process dynamic characteristic, obtaining the apparent adsorption coefficients of a fast component A and a slow component B, controlling the Relative flow rate ratio m alpha of a II band and a III band of SMB is in a triangle area formed by the apparent adsorption coefficients of the fast component A and the slow component B, and can optimizing the operation parameter of the target object and the interfering component.

Description

technical field [0001] The invention relates to the technical field of chromatography, in particular to a triangular optimization method for separating target objects in complex objects by simulated moving bed chromatography. Background technique [0002] Simulated moving bed (SMB) chromatographic technology has the characteristics of continuous, automatic and efficient, and has become a high-end separation technology in the fields of petrochemical, fine chemical and pharmaceutical (especially chiral drug resolution and biological product separation). Generally speaking, the operating variables of SMB include: switching period, sample liquid composition and concentration, mobile phase circulation flow rate, mobile phase inlet flow rate, extraction liquid flow rate, sample liquid flow rate and residual liquid flow rate; SMB inspection performance indicators include: product Purity, recovery, yield, mobile phase consumption and stationary phase usage. In order to maximize the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 王绍艳张志强路来菊
Owner UNIV OF SCI & TECH LIAONING
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