Echinococcosis patient serum spectral recognition method based on principal component analysis and BP neural network
A principal component analysis and neural network technology, applied in material excitation analysis, Raman scattering, etc., can solve the problems of clinical diagnosis that have not been reported, and achieve the effect of easy implementation, convenient operation and high diagnostic accuracy.
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Embodiment 1
[0018] Embodiment 1, the spectral identification method of the echinococcosis patient's serum based on the principal component analysis-BP neural network, is carried out according to the following steps: the first step, absorb the blood of at least 20 healthy people and at least 20 echinococcosis patients respectively Serum, and the absorbed serum is placed in a Raman spectrometer for full-wavelength scanning and data collection; the Raman spectrometer can use the Raman spectrometer of horiba company, and use the supporting software LabSpec 6 to collect data;
[0019] The second step is to normalize the collected data; in order to eliminate the noise generated by light source interference and collection methods when the instrument collects the spectrum, it is necessary to preprocess the collected raw data before analysis. Pre-process the collected raw data to eliminate the effects of light scattering, sample inhomogeneity, etc.;
[0020] The third step is to conduct principal ...
Embodiment 2
[0022] Embodiment 2, according to the hidden layer of the BP neural network, the required input parameters of the s-type activation function logsig are distributed between [0,1], and the input and output values are defined in the range of [0,1], normalized The algorithm adopts the formula: χ i ’=(χ i -χ min ) / (χ max -χ min ), where χ i is the data that needs to be normalized, χ i ’ is the normalized sample data, χ min for χ i The minimum value in χ max for χ i the maximum value in .
[0023] 1. Experiments and methods
[0024] 1.1 Blood samples and instruments
[0025] Blood: 38 cases of healthy people with clear diagnosis and complete data were taken randomly, and 28 cases of echinococcosis patients were provided by the First Affiliated Hospital of Xinjiang Medical University.
[0026] Instrument: The Raman spectrometer of Horiba Company was used in the experiment, the measured wavelength range was 101.298nm to 3999.76nm, and the resolution was less than 0.02nm....
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