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Extraction method and application of phenanthrene compounds from overground part of Chinese yam

A technology of aerial part and extraction method, which is applied in the field of separation and application of the effective components of the aerial part of yam, and can solve the problems of no research report on hypoglycemia and less research

Active Publication Date: 2017-04-19
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few studies on the aerial part of yam, and there is no research report on its ability to lower blood sugar.

Method used

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  • Extraction method and application of phenanthrene compounds from overground part of Chinese yam
  • Extraction method and application of phenanthrene compounds from overground part of Chinese yam
  • Extraction method and application of phenanthrene compounds from overground part of Chinese yam

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Shade-dried 8.5kg of aerial part of yam, crushed, extracted by percolation with ethanol with a volume fraction of 95%, combined extracts, concentrated under reduced pressure to obtain 871.5g of total extract, suspended in 2 times the amount of water, and washed with 5 Double the amount of petroleum ether and ethyl acetate for extraction, the ethyl acetate extract was collected and concentrated under reduced pressure to obtain 100.2 g of ethyl acetate extract. The ethyl acetate extract was subjected to Diaion HP-20 type macroporous adsorption resin column chromatography, eluted with 60% ethanol and 80% ethanol in sequence, and collected 80% ethanol for elution. liquid and concentrated under reduced pressure to obtain 45.7 g of 80% ethanol-eluted product. The product was eluted with 80% ethanol and subjected to normal pressure silica gel column chromatography, using petroleum ether-acetone (volume ratios of 5:1, 3:1, 2:1 and 1:1) and dichloromethane-methanol (volume ratio...

Embodiment 2

[0024] Shade-dried 8.5kg of aerial part of yam, crushed, extracted by percolation with ethanol with a volume fraction of 95%, combined the extracts, concentrated under reduced pressure to obtain 871.5g of total extract, suspended the extract in 2 times the amount of water, and washed with 5 Double the amount of petroleum ether and ethyl acetate for extraction, the ethyl acetate extract was collected and concentrated under reduced pressure to obtain 100.2 g of ethyl acetate extract. The ethyl acetate extract was subjected to Diaion HP-20 type macroporous adsorption resin column chromatography, eluted with 60% ethanol and 80% ethanol in sequence, and collected 80% ethanol for elution. liquid and concentrated under reduced pressure to obtain 45.7 g of 80% ethanol-eluted product. The product was eluted with 80% ethanol and subjected to normal pressure silica gel column chromatography, using petroleum ether-acetone (volume ratios of 5:1, 3:1, 2:1 and 1:1) and dichloromethane-methan...

Embodiment 3

[0027] Shade-dried 8.5kg of aerial part of yam, crushed, extracted by percolation with ethanol with a volume fraction of 95%, combined the extracts, concentrated under reduced pressure to obtain 871.5g of total extract, suspended the extract in 2 times the amount of water, and washed with 5 Double the amount of petroleum ether and ethyl acetate for extraction, the ethyl acetate extract was collected and concentrated under reduced pressure to obtain 100.2 g of ethyl acetate extract. The ethyl acetate extract was subjected to Diaion HP-20 type macroporous adsorption resin column chromatography, eluted with 80% ethanol and 95% ethanol in sequence, and collected 95% ethanol for elution. liquid and concentrated under reduced pressure to obtain 25.0 g of 95% ethanol-eluted product. The product was eluted with 95% ethanol and subjected to normal pressure silica gel column chromatography, using petroleum ether-acetone (volume ratios of 5:1, 3:1, 2:1 and 1:1) and dichloromethane-methan...

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Abstract

The invention discloses an extraction method and application of phenanthrene compounds from the overground part of Chinese yam, belonging to the technical field of separation and application of the active components of the overground part of Chinese yam. According to a technical scheme in the invention, the method comprises the following main steps: subjecting the coarse powder of the overground part of Chinese yam to percolation and extraction with ethanol and then carrying out concentration; then extracting extract obtained in the previous step with an organic solvent; and then carrying out separation by using macroporous adsorption resin, gel and Sephadex column chromatography and other column chromatography so as to obtain the phenanthrene compounds. Four phenanthrene compounds extracted from the overground part of Chinese yam all show substantial inhibitory activities to alpha-glucosidase, and the activities are all better than the activity of the hypoglycemic agent acarbose under same conditions.

Description

technical field [0001] The invention belongs to the technical field of separation and application of effective components in aerial parts of yams, and in particular relates to an extraction method and application of phenanthrene compounds in aerial parts of yams. Background technique [0002] Due to many factors such as the improvement of people's living standards, changes in diet structure, and less active and more sedentary lifestyle, the incidence of diabetes worldwide has increased rapidly. Diabetes has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. . The first symptom in the pathogenesis of diabetes is often postprandial hyperglycemia, which is the early sign of diabetes, especially for patients with type Ⅱ diabetes. Postprandial hyperglycemia not only easily induces various complications, but also greatly increases the risk of diabetes. mortality rate. Therefore, reducing postprandial blood sugar is on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C46/10C07C50/34C07C41/36C07C41/34C07C43/23A61P3/10
CPCC07C41/34C07C41/36C07C43/23C07C46/10C07C50/34
Inventor 张来宾吕洁丽刘军伟
Owner XINXIANG MEDICAL UNIV
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