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Traditional Chinese medicinal composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as poor product quality controllability and unreasonable production process, and achieve the effect of enhancing quality controllability, improving product curative effect, and improving curative effect

Inactive Publication Date: 2017-03-22
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems existing in the existing technology such as unreasonable production process, poor controllability of product quality and need for further improvement of curative effect

Method used

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  • Traditional Chinese medicinal composition and preparation method thereof
  • Traditional Chinese medicinal composition and preparation method thereof
  • Traditional Chinese medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription

[0036] Bupleurum 250g, skullcap 125g, kudzu root 125g, buffalo horn 62.5g, honeysuckle 187.5g, isatidis 250g, forsythia 150g and rhubarb 62.5g

[0037] Preparation

[0038] 1) Ultrasonic-assisted hydrolysis of buffalo horn in 5 times the hydrochloric acid solution with a concentration of 0.2mol / L. The hydrolysis time is 6 hours. The obtained extract is ultrafiltered by a 30KD molecular weight ultrafiltration device to obtain the filtrate and dried to obtain the buffalo horn extract, which is the substance a.

[0039] 2) Soak Banlangen, Bupleurum, Honeysuckle, and Forsythia in water for 10 minutes with 6 times the amount of water by weight, distill and extract volatile oil for 6 hours, and distill and extract 3 times at a distillation temperature of 90°C to obtain distillate and collect distillate , that is to obtain the volatile oil of Radix Radix, Bupleurum, Honeysuckle, Forsythia, and the dregs for later use; the ratio of volatile oil of Radix Radix R...

Embodiment 2

[0044] prescription

[0045]Bupleurum 250g, skullcap 125g, kudzu root 125g, buffalo horn 62.5g, honeysuckle 187.5g, isatidis 250g, forsythia 150g and rhubarb 62.5g

[0046] Preparation

[0047] 1) Ultrasonic-assisted hydrolysis of buffalo horn in a protease solution with an 8-fold concentration of 200U / g. The hydrolysis time is 6 hours. The obtained extract is ultrafiltered by a 40KD molecular weight ultrafiltration device to obtain the filtrate and dried to obtain the buffalo horn extract, which is Substance A .

[0048] 2) Soak Radix Isatidis, Bupleurum, Honeysuckle, and Forsythia in water for 30 minutes by adding 8 times the amount of water according to the weight ratio, distill and extract volatile oil for 3 hours, distill and extract twice, and distill at 100°C to obtain distillate and collect distillate , that is to obtain the volatile oil of Radix Radix, Bupleurum, Honeysuckle, and Forsythia, and the dregs for future use; the ratio of volatile oil to cyclodextrin of R...

Embodiment 3

[0053] prescription

[0054] Bupleurum 160g, skullcap 160g, kudzu root 160g, buffalo horn 40g, honeysuckle 240g, isatidis 160g, forsythia 96g and rhubarb 80g.

[0055] Preparation

[0056] Ultrasonic-assisted hydrolysis of buffalo horn in 10 times the protease solution with a concentration of 6000U / g, hydrolyzed 3 times, each time the hydrolysis time was 0.5h, the obtained extract was ultrafiltered by a 50KD molecular weight ultrafiltration device to obtain the filtrate and dried to obtain The buffalo horn extract is Substance A.

[0057] Soak Banlangen, Bupleurum, Honeysuckle, and Forsythia in water for 60 minutes by adding 10 times the amount of water by weight, distill and extract volatile oil once, 5 hours each time, and distill at 100°C to obtain distillate, collect the distillate, that is Obtain the volatile oil of Radix Isatidis, Bupleurum, Honeysuckle, and Forsythia, and use the dregs for later use; the ratio of volatile oil to cyclodextrin of Radix Isatidis, Bupleur...

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Abstract

The invention provides a traditional Chinese medicinal composition and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition contains baicalin, puerarin, chlorogenic acid, rheum emodin, and also contains forsythin, total volatile oil and total amino acids. Specifically, the traditional Chinese medicinal composition is prepared by processing the following materials in parts by weight: 250 parts of radix bupleuri, 125 parts of radix scutellariae, 125 parts of radix puerariae, 62.5 parts of cornu bubali, 187.5 parts of honeysuckle flowers, 250 parts of isatis root, 150 parts of fructus forsythiae, and 62.5 parts of radix et rhizoma rhei. The invention further provides the preparation method of the traditional Chinese medicinal composition. According to the composition, the quality standard of the product is improved, the quality controllability is enhanced, meanwhile, the content of active ingredients in the product is improved, and the curative effects of the product are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Exogenous fever is one of the most common clinical symptoms in children, with fever, nasal congestion, runny nose, sneezing, and throat irritation as the main clinical manifestations. It is caused by children suffering from wind-heat and wind-cold evil, accompanied by nasal congestion, runny nose, delayed discomfort, fatigue, headache, joint pain and cough. The theory of traditional Chinese medicine believes that children have a body of immature yin and yang, with soft skin, weak lung and defense functions, low immunity, and are easily attacked by wind and pathogenic factors; they are prone to cold and heat, and they change rapidly. is the main cause of fever. The heresy of wind-heat and wind-cold, the external muscle surface, internally invades the disease of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61P29/00A61P11/00A61K35/32
CPCA61K36/233A61K35/32A61K36/195A61K36/315A61K36/355A61K36/488A61K36/539A61K36/634A61K36/708A61K2236/331A61K2236/39A61K2236/53
Inventor 方同华周广红崔玉海贾文娟范玉奇王春生
Owner HEILONGJIANG ZBD PHARMA
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