Drug for treating lupus nephropathy and preparation method and application of drug

A lupus nephritis and drug technology, applied in the field of medicine, can solve the problems of long treatment time and high disease recurrence rate, and achieve the effects of stable curative effect, consolidation of curative effect, and safe and convenient use.

Inactive Publication Date: 2017-03-22
ZHENGZHOU ZHANGMENG NETWORK TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies in recent years have shown that the use of traditional Chinese medicine in the treatment of lupus nephritis can improve the curative effect and have low side effects, but the treatment time is long and the recurrence rate of the disease is high

Method used

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  • Drug for treating lupus nephropathy and preparation method and application of drug
  • Drug for treating lupus nephropathy and preparation method and application of drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In the embodiment of the present invention, a medicine for treating lupus nephritis is composed of the following raw materials: 1 part of hexamethyldisilazane, 11 parts of difluben salicylic acid, 13 parts of bellflower, and 8 parts of astragalus.

[0019] Diflunisalicylic acid and Platycodon grandiflora were mixed and ground, then deionized water 4.5 times the mass of the two was added, heated to 75°C and stirred at this temperature for 25 minutes to prepare mixture A. Hexamethyldisilazane was put into mixture A, and then sealed and stirred at a temperature of 88° C. for 33 minutes to prepare mixture B. Then add Radix Astragali, and then ultrasonically treat at 63° C. for 15 minutes with an ultrasonic power of 900 W, then stir at 75° C. until dry, and granulate to obtain the drug.

Embodiment 2

[0021] In the embodiment of the present invention, a medicine for treating lupus nephritis is composed of the following raw materials: 5 parts of hexamethyldisilazane, 19 parts of difluben salicylic acid, 21 parts of bellflower, and 16 parts of astragalus.

[0022] Mix and grind difluben salicylic acid and Platycodon grandiflorum, then add deionized water 4.5 times the mass of the two, heat to 75°C and stir at this temperature for 28 minutes to prepare mixture A. Hexamethyldisilazane was put into mixture A, and then sealed and stirred at a temperature of 88° C. for 35 minutes to prepare mixture B. Then add Radix Astragali, and then ultrasonically treat at 63° C. for 15 minutes with an ultrasonic power of 900 W, then stir at 75° C. until dry, and granulate to obtain the drug.

Embodiment 3

[0024] In the embodiment of the present invention, a medicine for treating lupus nephritis is composed of the following raw materials: 2 parts of hexamethyldisilazane, 13 parts of difluben salicylic acid, 15 parts of bellflower, and 10 parts of astragalus.

[0025] Diflunisalicylic acid and Platycodon grandiflora were mixed and ground, then 4.5 times the mass of the two was added in deionized water, heated to 75°C and stirred at this temperature for 26 minutes to prepare mixture A. Hexamethyldisilazane was put into mixture A, and then sealed and stirred at a temperature of 88° C. for 34 minutes to prepare mixture B. Then add Radix Astragali, and then ultrasonically treat at 63° C. for 15 minutes with an ultrasonic power of 900 W, then stir at 75° C. until dry, and granulate to obtain the drug.

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Abstract

The invention discloses a drug for treating lupus nephropathy and a preparation method and application of the drug. The drug consists of the following raw materials: 1-5 parts of hexamethyl disilazane, 11-19 parts of diflunisal, 13-21 parts of Radix Platycodonis and 8-16 parts of Radix Astragali. The preparation method comprises the following steps: mixing and grinding the diflunisal and the Radix Platycodonis, then adding deionized water, heating to the temperature of 75 DEG C, and stirring at the temperature to obtain a mixture A; and placing the hexamethyl disilazane in the mixture A, then sealing and stirring at the temperature of 88 DEG C, adding the Radix Astragali, carrying out ultrasonic treatment for 15 minutes at the temperature of 63 DEG C, stirring at the temperature of 75 DEG C, and granulating to obtain the final product. The drug for treating the lupus nephropathy is remarkable in curative effect, meanwhile, reduction of hormone is facilitated, complications in a treatment process are reduced, the curative effect is consolidated, remarkable, definite and stable, the drug is safe and convenient to use, and does not have any toxic and side effects, the lupus nephropathy does not relapse after being healed, and the drug is low in price and is worthy of being popularized clinically.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating lupus nephritis and its preparation method and application. Background technique [0002] Lupus nephritis refers to a disease in which systemic lupus erythematosus (SLE) is combined with different pathological types of immune damage in both kidneys, accompanied by clinical manifestations of obvious kidney damage. Its pathogenesis is related to immune abnormalities such as the formation of immune complexes, immune cells and cytokines. In addition to the systemic manifestations of SLE, the main clinical manifestations are hematuria, proteinuria, and renal insufficiency. The pathological classification of lupus nephritis is of great value in judging disease activity and prognosis, and formulating treatment plans. The treatment plan should be formulated individually according to the severity of the disease. The pathogenesis of lupus nephritis may be relate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/16A61P13/12A61P37/02A61K31/60A61K31/695
CPCA61K31/695A61K9/1605A61K31/60A61K36/346A61K36/481
Inventor 不公告发明人
Owner ZHENGZHOU ZHANGMENG NETWORK TECH CO LTD
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