Method for preparation of fluorescent silica nanoparticles

Abstract

The invention provides a method for preparation of fluorescent silica nanoparticles. The method includes: a), mixing indocyanine type fluorescent dye with an organic silicon source compound to obtain a precursor solution; b), allowing the precursor solution to react under constant temperature to obtain the fluorescent silica nanoparticles. The water-soluble fluorescent silica nanopartricles are prepared with the one-step method which is performed completely in water phase, so that the method is safe in operation, rapid and convenient, low in toxicity and safe and easy in obtaining raw materials; the water-soluble fluorescent silica nanoparticles are quite good in monodispersity, high in fluorescent property and quantum yield, good in stability, good in water solubility, capable of serving as fluorescence indicators widely applied to biological detection and analysis and hopeful to be used for optical related industrial production such as laser and organic light emitting diodes.

Description

technical field [0001] The invention relates to the field of nanotechnology, in particular to a method for preparing fluorescent silicon nanoparticles. Background technique [0002] Functional silicon nanomaterials have attracted increasing attention from scientists due to their unique optical / electrical / mechanical properties, surface modifiability, and good biocompatibility. What deserves special attention is that fluorescent silicon nanoparticles, as a representative zero-dimensional silicon nanomaterial, are expected to be widely used in biology and medicine because of their good biocompatibility and low toxicity. However, most of the fluorescent silicon nanoparticles have hydrophobic groups on the surface, resulting in poor water dispersibility, which cannot meet the requirements of biological applications. Over the past few years, scientists have developed different approaches to modify the surface of hydrophobic silicon nanoparticles with hydrophilic groups such as hy...

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Problems solved by technology

[0003] However, although these methods can greatly enhance the water dispersibility of silicon nanoparticles, the process is relatively complicated (for example, it is first necessary to prepare hydrophobic silicon nanoparticles, and then modify them with hydrophilic groups) , and it is easy to damage the surface of silicon nanoparticles during the modification process, which affects its physical / chemical properties (the pH stability of silicon nanoparticles modified by acrylic acid / allylamine is not good; the size of silicon nanoparticles modified by polymer / microbeams is too large (60- 300nm))

[0004] In recent years, although there are also reports on water-soluble silicon nanoparticles, most of the methods require the use of relatively expensive instruments and equipment (such as microwave instruments, glove boxes, plasma reactors, etc.), as well as relatively complicated process steps and operations and harsh conditions. The reaction conditions limit the application and promotion of fluorescent silicon nanoparticles

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