Antimicrobial articles produced by additive manufacturing

A technology of products and antibiotics, applied in the field of implantable medical devices, which can solve the problems of limited drug load limit and weakening of curative effect over time

Inactive Publication Date: 2017-02-22
ORTHOPAEDIC INNOVATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, drug-eluting implants are known to be less effective over time and are limited by drug loading limits during implant preparation
Implants with drug-loaded grooves / fissures avoid infection around the fissure for some time, but are susceptible to microbial colonization and biofilm formation on their surface areas away from the groove / fissure location

Method used

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  • Antimicrobial articles produced by additive manufacturing
  • Antimicrobial articles produced by additive manufacturing
  • Antimicrobial articles produced by additive manufacturing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]Polylactic acid (PLA) particles were from NatureWorks LLC (Blair, NE, USA). Polycaprolactone (PCL) particles (CAPA™ 6500) were from Plastics Systems Inc. (Lakewood, WA, USA). Vancomycin and gentamicin were from Gold Biotechnology (St. Louis, MO, USA). A PLA blend containing approximately 5% vancomycin was prepared by dry blending 0.28 kg of vancomycin with a 5.8 Kg batch of PLA granules. A PLA blend containing about 2% vancomycin was prepared by dry blending 0.122 kg of vancomycin with a 5.8 Kg batch of PLA granules. A PCL blend containing about 5% gentamicin was prepared by dry blending 0.125 Kg of gentamicin with a 2.5 Kg batch of PCL granules. A PCL blend containing about 2% gentamicin was prepared by dry blending a PCL blend containing about 5% gentamicin with additional PCL to adjust the gentamicin content to about 2%.

[0029] use HiQ system (SINTERSTATION and SLS are registered trademarks of 3D Systems Inc., Valencia, CA, USA), from each batch of polymer / an...

Embodiment 2

[0049] The selected tensile properties of antibiotic-containing plastic Type IV dumbbell test specimens were determined according to the test method set forth in ASTM D638-08 document entitled "Standard Test Method for Tensile Properties of Plastics". Physical Properties, the test methods are published by ASTM International (International Society for Testing and Materials) and are publicly available from their web site at http: / / www.astm.org / Standards / D638.htm. The physical properties of the SLS-printed plastic discs containing antibiotics are listed in Tables 1–4.

[0050] Table 1: Physical properties of Type IV dumbbell-shaped samples printed with PCL / gentamicin dry blend*

[0051]

[0052] *Data are the mean ± SD of three replicates

[0053] Table 2: Physical properties of type IV dumbbell-shaped samples printed with PCL / vancomycin dry blend*

[0054]

[0055] *Data are the mean ± SD of three replicates

[0056] Table 3: Physical properties of Type IV dumbbell-shap...

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PUM

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Abstract

An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a selective laser sintering process or a selective laser melting process or a selective heat sintering process or an electron beam melting process. The antibiotic-eluting article may be temporary or permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, and / or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material. The implantable device may be a cardiac pacemaker, a spinal cord stimulator, a neurostimulation system, an intrathecal drug pump for delivery of medicants into the spinal fluid, and infusion pump for delivery of chemotherapeutics and / or anti-spasmodics, an insulin pump, an osmotic pump, and a heparin pump.

Description

technical field [0001] Various embodiments disclosed herein generally relate to implantable medical devices. More specifically, this paper relates to implantable medical devices having antimicrobial properties in their structure and on their surfaces. [0002] technical background [0003] Many types of medical devices have been developed for implantation in a patient's body. For example, it has become common practice for dentists to provide their patients with custom dental prostheses and / or implants to replace non-functional or missing teeth. Such surrogate prostheses and / or implants can be individually designed and prepared for precise fitting to specific intended sites. It has become routine practice to place a pacemaker device under the skin in the chest area or in the abdomen of patients with abnormal or irregular heart contractions. Patients with debilitating degenerative diseases affecting their joints and / or bone elements are now able to restore their There is a ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61K31/7036A61K38/14A61K47/30A61K9/00A61L27/54A61P31/04
CPCA61K38/14A61K9/0024A61K47/32A61K47/38A61L27/14A61L27/34A61L2300/102A61L2300/404A61L2300/406A61L2430/02A61L2430/24A61M5/14276A61C13/0018A61C13/0019B29C64/153A61L27/54A61F2240/001A61K31/7036A61P31/00A61P31/04B33Y70/00B33Y10/00B33Y80/00A61B2017/00526A61B2017/00889A61F2002/30968A61F2002/3097A61F2002/30985A61K47/34A61L27/18A61L2430/12A61M2205/0205A61M2207/00A61N1/00B29C35/0805B29C35/0866B29C2035/0838B29C2035/0877B29K2067/046B29K2105/251B29K2995/0037B29L2031/7532
Inventor 马丁·皮彻卢克·M.b·罗杰斯
Owner ORTHOPAEDIC INNOVATION CENT
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