A kind of high surface tension hydrogel glass body substitute and radiation preparation method thereof

Abstract

The invention discloses a high-surface-tension hydrogel vitreous substitute and a radiation preparation method thereof. The preparation method comprises the following steps: performing ultrasonic stirring on natural polysaccharides, supermolecules, a radiation sensitizer, a pH adjuster and a solvent which serve as main components to prepare a uniform dispersion system, feeding N2 for stewing and debubbling at negative pressure, performing vacuum encapsulation and quick circulating freezing-defreezing, and performing radiation crosslinking reaction on the dispersion system with the natural polysaccharides and the supermolecules, which serve as base materials, under ionizing radiation to prepare the high-surface-tension hydrogel vitreous substitute. The product is emulsification-free and dispersion-free, is higher in surface tension, can be self-degraded and absorbed slowly, is relatively long in metabolic time, can up press irregular surfaces and effectively close a retinal hole, is not liable to enter a retina, and has the characteristics of high light transparency, viscoelasticity, shock absorption property, uniformity, biological compatibility, safety and the like; preparation, plasticization, sterilization and the like can be synchronously completed, and a production process is simplified.

Description

technical field [0001] The invention relates to a high surface tension hydrogel vitreous substitute and a radiation preparation method thereof, in particular to a high surface tension hydrogel vitreous substitute prepared by radiation crosslinking with natural polysaccharides and supramolecules as substrates method. Background technique [0002] Retinal detachment is one of the most serious blinding eye diseases. The cause of the disease is the degeneration of the retina and vitreous body. The aqueous humor and liquefied vitreous body flow through the retinal break to between the retinal neuroepithelium and the pigment epithelium, resulting in retinal bulge detachment. The emergence of vitreous surgery and the update and clinical application of various vitreous substitutes have greatly promoted the treatment of retinal detachment, making many types (such as giant hole, macular hole, combined vitreous opacity, proliferative vitreoretinopathy, choroidal detachment) Retinal d...

AI Technical Summary

Problems solved by technology

Among them, water cannot effectively press the retinal tear, so it cannot be used for the treatment of retinal detachment; although the gas can seal the tear, its expansion can cause high intraocular pressure, and the irregular scattering of light by the gas itself makes the postoperative vision of the patient within a certain period of time (about one month) is relatively poor, causing psychological fear and worry in patients; perfluorocarbon liquid has retinal toxicity; although silicone oil can not only press the fractured hole (generally, the surface tension is 40mN / m), but also make the patient feel healthy after surgery. A clearer vision, but it also has obvious defects: 1. Silicone oil affects the metabolism of intraocular tissues, leading to concurrent cataracts and corneal degeneration; 2. Silicone oil emulsification can block the angle of the chamber and cause secondary glaucoma; emulsified Silicone oil droplets are also neurotoxic, leading to retinal optic nerve degeneration; 3. They cannot be absorbed or degraded by themselves, and need to be removed by surgery again

[0006] At present, the composition, morphology and preparation method of hydrogel vitreous body are too simple, especially the preparation method is still limited to the traditional freezing and chemical cross-linking methods.