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A kind of natural polysaccharide/nano tio 2 Composite hydrogel photosensitive antibacterial dressing and radiation synthesis method

A natural polysaccharide and composite hydrogel technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as limiting the application of functional materials, and achieve the effects of keeping the wound environment moist, saving production costs, and enhancing antibacterial effects.

Active Publication Date: 2018-01-19
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single-component materials often have deficiencies in practical applications (especially in terms of mechanical properties and biological and physiological functions), which limits their application as functional materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Take carboxymethyl chitosan 3.64g, nano TiO 2 0.036g, polyvinyl alcohol (polymerization degree 1670) 0.036g, sodium dihydrogen phosphate 0.364g, Tween 0.036g and water 32ml for later use;

[0035] 2. Take 25ml of the above deionized water, nano-TiO 2 , Tween are added to the container in turn, placed in an ultrasonic generator and ultrasonicated for 1 hour to form stable nano-TiO 2 Emulsion system;

[0036] 3. Take polyvinyl alcohol (polymerization degree 1670) and put it into 7ml deionized water at 95°C, stir at 150r / min, heat and stir for 2h, after completely dissolving, cool to 50°C, add carboxymethyl chitosan respectively , Sodium dihydrogen phosphate, stirred for 1 hour to make it completely dissolved to form a uniform solution;

[0037] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 Mix the emulsion system, stir for 0.5h and then let it stand for 2h, vacuumize and defoam and inject into 15×5×1mm 3 In the PE mold, rapid vacuu...

Embodiment 2

[0042] 1. Take 40g of sodium carboxymethylcellulose, 3g of collagen, 5g of P25, and nano-TiO sensitized with CdTe quantum dots 2 5g, 3g of sodium hydroxide, 1g of Span, 1g of Tween, 1g of Brij and 43ml of water for later use;

[0043] 2. Take the above deionized water 17ml, P25, CdTe quantum dot sensitized modified nano-TiO 2 , Span, Tween, and Brij were added to the container in turn, placed in an ultrasonic generator and ultrasonicated for 1 hour to form stable nano-TiO 2 Emulsion system;

[0044] 3. Put 40g sodium carboxymethylcellulose, 3g collagen, and 3g sodium hydroxide into 26ml deionized water at 35°C, heat and stir for 2 hours, and add nano-TiO 2 In the colloidal system;

[0045] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 The colloidal system is mixed, stirred for 0.5h and then left to stand for 2h. The uniformly stirred jelly-like sample is ground and pressed into a ball. After being pressed with a tablet machine, it is put int...

Embodiment 3

[0050] 1. Take 1g of bacterial cellulose and Se-doped modified nano-TiO 2 0.1g, polyvinyl alcohol (polymerization degree 1670) 6g, sodium dihydrogen phosphate 0.1g, disodium hydrogen phosphate 0.1g, glyceryl monostearate 0.1g, Myrij 0.1g and water 50ml for later use;

[0051] 2. Take 25ml of the above deionized water, Se-doped and modified nano-TiO 2 , glyceryl monostearate, and Myrij were added to the container in turn, and placed in an ultrasonic generator for 1 hour of ultrasonication to form stable nano-TiO 2 Emulsion system;

[0052] 3. Take polyvinyl alcohol (polymerization degree 1670) and put it into 25ml deionized water at 95°C, stir at 150r / min, heat and stir for 2h, after completely dissolving, cool to 50°C, add bacterial cellulose and hydrogen phosphate respectively Disodium, sodium dihydrogen phosphate, stirred for 1 hour, completely dissolved to form a uniform solution;

[0053] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 Mi...

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Abstract

The invention provides a natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing which is composed of a backing layer, a hydrogel dressing layer and a strippable layer. A synthesis method of the natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing comprises performing radiation crosslinking on raw materials, namely 10-40% of natural polysaccharide, 0.1-10% of nano-TiO2, 0.1%-5% of radiation sensitizer, 0.1%-3% of pH regulator, 0.1%-3% of surfactant and 60%-95% of water, by use of an electron beam or gamma ray by a radiation dose of 10-150kGy and at a dose rate of 10-80kGy / pass. The natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing is sheared, bagged and sterilized by radiation, and then stored for a long time. The natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing has the advantages that the maximization and optimization of the properties of the composite hydrogel, light-sensitive and antimicrobial properties are united organically, and the multiple-element composite synergic antimicrobial effect of the nano-TiO2-natural polysaccharide hydrogel is also realized; meanwhile, the composite hydrogel dressing has the characteristics of air permeability, no bonding with tissues, good flexibility and the like, and thus is suitable for protecting and treating various wounds.

Description

technical field [0001] The invention relates to a nanocomposite hydrogel antibacterial dressing, in particular to a natural polysaccharide / nano TiO 2 Composite hydrogel photosensitive antibacterial dressing and radiation synthesis method. Background technique [0002] Traditional hydrogel dressings have the advantages of absorbing wound exudate, keeping the wound moist, reducing scar formation, and promoting wound healing, and have attracted more and more attention. It is especially suitable for the protection and treatment of wounds, scalds, burns and other wounds. These hydrogel dressing products are generally thick, which increases the production cost, weakens the comfort of the product to a certain extent, and does not have a good antibacterial effect under natural light. From the perspective of the structure of traditional hydrogel dressing products, there is a certain air permeability, but the water absorption capacity of the ordinary adhesive layer is not strong, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61L15/28A61L15/18A61L15/42A61L15/44C08J3/28C08J3/24C08J3/075
Inventor 李月生赵龙
Owner HUBEI UNIV OF SCI & TECH
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