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Polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity

A technology of polymethoxylated flavonoids and pharmaceutical preparations, which is applied in the field of medicine and can solve problems such as side effects and affecting the normal metabolism of the body

Active Publication Date: 2017-02-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the commonly used weight loss methods include enema weight loss method, osmotic pressure weight loss method, etc., but the root cause of obesity is that fat has not been decomposed, and it will also affect the normal metabolism of the body
Clinically used drugs for weight loss, such as amphetamine and its derivatives, orlistat, L-carnitine, etc., are not ideal, and chemical drugs often cause serious side effects in the course of medication. Therefore, it is urgent to find an effective treatment for obesity. Drugs with less side effects

Method used

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  • Polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity
  • Polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity
  • Polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity

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Embodiment Construction

[0019] The technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0020] experimental method:

[0021] 1. Establishment of animal models

[0022] Take 60 C57BL / 6 male mice, weighing 18-20 g, aged 6 weeks. After one week of adaptation, the mice were randomly divided into: normal chow diet (NCD), high fat diet (HFD), 3,5,6,7,8,3',4'-heptagram Low-dose oxyflavone group (HMF-L) and high-dose 3,5,6,7,8,3',4'-heptamethoxyflavone group (HMF-H), all groups except normal feed group Adopt a Western-style diet. The Western-style diet feed formula is: 1.25% cholesterol, 20% lard, 5% sucrose, 0.5% cholic acid, vitamins adjusted to normal levels.

[0023] 2. Dosage and administration method: HFD-induced obesity experiments were carried out in mice by intragastric administration. Modeling began to administer drugs, and NCD and HFD were given the same volume of 0.5% CMC-Na solution for a total of six...

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Abstract

The invention discloses polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity. Active ingredients of the drug for preventing or treating obesity comprise polymethoxylated flavones being 3,5,6,7,8,3',4'-heptemthoxyflavone. In addition, the pharmaceutic preparation for preventing or treating obesity includes a pharmaceutically acceptable vector or excipient and thus a pharmaceutically acceptable dosage form is made. Adipose tissue accumulation causes obesity. Experiments demonstrate that the 3,5,6,7,8,3',4'-heptemthoxyflavone (HMF) enables adipose tissues to decrease obviously without affecting food intake, thereby suppressing adipose tissue accumulation and thus preventing or treating obesity.

Description

technical field [0001] The invention belongs to the field of medicine, relates to new applications of natural products, and in particular to polymethoxylated flavones, compositions and pharmaceutical preparations for preventing or treating obesity. Background technique [0002] Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Obesity can cause a variety of diseases, such as high blood pressure, coronary heart disease, angina pectoris, cerebrovascular disease, diabetes, hyperlipidemia, hyperuricemia, irregular menstruation, etc., and can also increase the risk of malignant tumors. morbidity. The mortality rate of obese people is significantly higher than that of normal weight people. Studies have shown that the death rate of obese people due to diabetes is significantly higher than that of normal weight people by 38.3% (male) and 37.2% (female); the death ra...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/04
CPCA61K31/352
Inventor 刘鄂湖谢志深肖娉婷
Owner CHINA PHARM UNIV
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