Solid dispersion capsules for treating peptic ulcer

Abstract

The invention provides solid dispersion capsules for treating peptic ulcer. The solid dispersion capsules are prepared by putting solid dispersion in capsules, wherein the solid dispersion is prepared from the active pharmaceutical ingredient powder and polyethylene glycol-6000 in a weight ratio of (1-2) to (3-5); and the active pharmaceutical ingredient powder is prepared by grinding the following active pharmaceutical ingredients in parts by weight into 200-500 meshes: 1-3 parts of daphne giraldii nitsche, 7-13 parts of rhizoma atractylodis macrocephalae, 2-3 parts of lucid ganoderma, 5-10 parts of codonopsis pilosula, 5-10 parts of radix pseudostellariae, 5-10 parts of capillary artemisia, 5-10 parts of dandelions, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin and 2-4 parts of nutmeg. According to the solid dispersion capsules, the active pharmaceutical ingredient powder is made into solid dispersion capsules, the bioavailability of the medicines is improved, and the anti-ulcer activity is obviously improved. However, the main defect of solid dispersion is that the solid dispersion is easily oxidized and aged in the storage process and consequently the dissolving speed is reduced. Therefore, by preparing the solid dispersion into the capsules, direct contact between air and the solid dispersion is avoided through capsule shells, and the aging is delayed.

Description

technical field [0001] The present invention relates to a solid dispersion capsule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to the localized circular or oval full-thickness defects of the gastric and duodenal mucosa. The muscularis mucosa is penetrated, and fibrous scars are inevitably left after healing, and the surface is a layer of epithelium. Covered, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it is believed that the formation of ulcers also has an important relationship with the infection of Helicobacter pylori in the stomach. [0003] Chronic superficial gastritis is a chronic superficial inflammation of the gastric mucosa, which is a common disease of the digestive system and is a type of chronic gastritis. It can be caused by alcoholism...

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs