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Drugs to treat pulmonary fibrosis

A technology of pulmonary fibrosis and drugs, applied in the field of drugs for the treatment of pulmonary fibrosis, can solve problems that are difficult to completely treat diseases with complex pathogenesis

Active Publication Date: 2020-05-29
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of single traditional Chinese medicine on pulmonary fibrosis is limited, and it is difficult to completely treat diseases with complex pathogenesis. Chinese medicine compound is the most difficult point of Chinese medicine research

Method used

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  • Drugs to treat pulmonary fibrosis
  • Drugs to treat pulmonary fibrosis
  • Drugs to treat pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: The Intervention Effect of Hamangfeixian Recipe on Pulmonary Fibrosis Model Mice

[0018] 1 Experimental materials

[0019] 1.1 Experimental animals

[0020] About 18-22g Kunming SPF grade male mice, certificate number: scxkgui 2009-0002, provided by the Experimental Animal Center of Guangxi Medical University.

[0021] 1.2 Drugs and reagents

[0022] Dexamethasone sodium phosphate injection (1ml, 5mg, Guangzhou Baiyunshan Tianxin Pharmaceutical Co., Ltd., production batch number: 130608); bleomycin hydrochloride for injection (Nippon Kayaku Co., Ltd., product batch number: 120901); gecko (Guangxi Yulin Shenbaotang Chinese Herbal Pieces Co., Ltd., product batch number: 130802); Wuzhi milk (Guangxi Yulin Shenbaotang Chinese Herbal Pieces Co., Ltd., product batch number: 130905); mango leaves (self-collected, identified by Qin Wenhui, Department of Chinese Medicine, Guangxi University of Traditional Chinese Medicine ); Panax notoginseng (Guangxi Yulin Shenba...

Embodiment 2

[0069] Example 2: Interventional effect of Hamangfeixian recipe on inflammation of human bronchial epithelial cells (BEAS-2B)

[0070] 1 material

[0071] 1.1 Main Instruments

[0072] Milli-Q ultrapure water instrument (Millipore, USA); HF151UV CO2 cell incubator (HealForce, Shanghai); inverted biological phase contrast microscope (Olympus, Japan); MIKRO 220R high-speed refrigerated centrifuge (Hettich, Germany); 680 type Microplate reader (Bio-Rad, USA); Modulus fluorescence detector (TurnerDesigns, USA).

[0073] 1.2 Drugs and reagents

[0074] Feixianfang, composed of Gecko, Wuzhi milk, mango leaves, yellow root and Panax notoginseng, was extracted and prepared by Tianjin Institute of Pharmaceutical Sciences; 1640 basal medium (HyClone, USA); double antibodies (ampicillin and streptomycin) , fetal bovine serum, trypsin (Gibco, USA); TNF-α (Peprotech, USA); dexamethasone (Dex, Sigma, USA); PGL4.32 plasmid and Renilla luciferase plasmid, cell lysate, double Luciferase re...

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Abstract

The invention discloses a medicine for treating pulmonary fibrosis. The medicine for treating the pulmonary fibrosis is characterized in that the medicine prescription consists of traditional Chinese medicine gecko, ficus hirta, mango leaves, prismatomeria tetrandra and panax notoginseng. In the prescription, the gecko and the ficus hirta serve as medicines for reinforcing deficiency and strengthening body resistance, the mango leaves serve as medicines for diminishing inflammation, relieving cough and reducing phlegm, and the prismatomeria tetrandra and the panax notoginseng serve as medicines for removing blood stasis and eliminating stagnation. The prescription realizes reasonable medicine use according to the traditional Chinese medicine thought about treatment based on syndrome differentiation so as to achieve the effect of treating both symptoms and root causes. Experimental research proves the effectiveness and the action mechanism of the prescription on the pulmonary fibrosis, and the prescription can be applied to novel traditional Chinese medicines for developing and treating the pulmonary fibrosis.

Description

technical field [0001] The invention belongs to the technical field of pulmonary fibrosis treatment, in particular to a medicine for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a type of disease in which diffuse exudation, infiltration and fibrosis of the pulmonary interstitium are the main lesions. Its main symptoms include dyspnea, shortness of breath, dry cough, and wheezing. die. At present, its pathogenesis is still unclear, and with the continuous deterioration of environmental pollution, the incidence rate is increasing year by year. At present, Western medicine mainly uses hormones and immunosuppressant drugs for the traditional treatment of pulmonary fibrosis, but the curative effect is not ideal and there are side effects. There is no disease name for pulmonary fibrosis in TCM literature. According to its symptoms, it can be classified as "pulmonary obstruction", "lung impotence", "cough", etc. Clinical and practice shows...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P11/00A61K35/583
CPCA61K35/583A61K36/22A61K36/258A61K36/60A61K36/74A61K2300/00
Inventor 邓家刚刘颖黄诗思张帅杜正彩白钢侯小涛郝二伟
Owner GUANGXI UNIV OF CHINESE MEDICINE
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