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Veterinary albendazole ivermectin premixing agent and preparation method thereof

A technology of albendazole ivermectin and ivermectin, which is applied in the field of veterinary albendazole ivermectin premix and its preparation, and can solve the problems affecting the main components of albendazole and ivermectin. To solve problems such as mycocin detection, small dosage of ivermectin, and detection content not up to the standard, to achieve the effect of low static electricity, reasonable selection, and convenient operation

Active Publication Date: 2017-02-15
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] According to the existing preparation method, there are mainly the following problems: (1) The dosage of ivermectin is small, and it is not easy to mix evenly. When the mixed feed is used, poisoning accidents often occur because of the inability to mix evenly.
[0009] (2) The biggest feature of activated carbon is its fast decolorization speed and strong adsorption capacity. After it is mixed with ivermectin and albendazole, it can absorb these two main drugs and affect the main components of albendazole and ivermectin. testing, resulting in the product being fed according to the formula quantity but the detected content is not up to the standard
(3) Albendazole is extremely difficult to dissolve, and it is easy to form agglomerates after mixing with general excipients, and it is difficult to disperse when mixed feed is used
[0010] At present, lack a kind of preparation method that obtains good veterinary albendazole ivermectin premix of product uniformity

Method used

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  • Veterinary albendazole ivermectin premixing agent and preparation method thereof
  • Veterinary albendazole ivermectin premixing agent and preparation method thereof
  • Veterinary albendazole ivermectin premixing agent and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0034] A kind of veterinary albendazole ivermectin premix of the present invention comprises the following components by mass percentage:

[0035]

[0036] The ivermectin pretreatment agent is a combination of four types of lecithin, hydrogenated castor oil, and hydrogenated soybean oil. The auxiliary material is a combination of two kinds of calcium carbonate and sodium citrate.

[0037] The preparation method of veterinary albendazole ivermectin premix of the present invention comprises the steps:

[0038] (1) Ivermectin pretreatment:

[0039] Accurately weigh each component according to the mass percentage;

[0040] Take ivermectin pretreatment agent, heat and melt; heating temperature is 100°C, add ivermectin, shear and stir evenly; spray and condense the prepared mixed solution to granulate, and the prepared granules have a particle size of 90 μm , and sieved to obtain powder A;

[0041] (2) Albendazole is uniformly mixed with 150 μm pulverized anhydrous glucose to...

Embodiment 2

[0044] The difference between embodiment 2 and embodiment 1 is: a kind of veterinary albendazole ivermectin premix of the present invention comprises the following components by mass percentage:

[0045]

[0046] The ivermectin pretreatment agent is wax. The waxes are a combination of white wax, paraffin wax, paraffin wax or beeswax. The auxiliary material is sodium citrate.

[0047] The preparation method of veterinary albendazole ivermectin premix of the present invention comprises the steps:

[0048] (1) Ivermectin pretreatment:

[0049] Accurately weigh each component according to the mass percentage;

[0050] Take the ivermectin pretreatment agent and heat and melt it; the heating temperature is 80°C, add the ivermectin, and carry out shearing and stirring; the prepared mixed solution is sprayed and condensed to granulate, and the prepared granules have a particle size of 180 μm, Sieve to obtain powder A;

[0051] In step (2), albendazole is uniformly mixed with 1...

Embodiment 3

[0054] The difference between embodiment 3 and embodiment 1 is: a kind of veterinary albendazole ivermectin premix of the present invention comprises the following components by mass percentage:

[0055]

[0056] The ivermectin pretreatment agent is a combination of three of Tween, lecithin and hydrogenated castor oil. The auxiliary material is silicon dioxide.

[0057] The preparation method of veterinary albendazole ivermectin premix of the present invention comprises the steps:

[0058] In step (1), ivermectin pretreatment:

[0059] Accurately weigh each component according to the mass percentage;

[0060]Take the ivermectin pretreatment agent, heat and melt; the heating temperature is 110°C, add the ivermectin, and carry out shearing and stirring; the prepared mixed solution is sprayed and condensed to granulate, and the prepared granules have a particle size of 150 μm , and sieved to obtain powder A;

[0061] In step (2), albendazole is uniformly mixed with 150 μm ...

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Abstract

The invention discloses a veterinary albendazole ivermectin premixing agent and a preparation method thereof. The veterinary albendazole ivermectin premixing agent disclosed by the invention comprises the following components in percentage by weight: 5.5-6.5 percent of albendazole, 0.22-0.26 percent of ivermectin, 5-15 percent of medicinal carbon, 5-10 percent of dextrose anhydrous, 30-59 percent of maize starch, 10-15 percent of an ivermectin pretreatment agent and the balance of an auxiliary material. The preparation method disclosed by the invention is simple in process, convenient to operate and easy to industrialize, and the product prepared by the preparation method disclosed by the invention is uniform in particle size, low in static electricity and good in uniformity.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a veterinary albendazole ivermectin premix and a preparation method thereof. Background technique [0002] Albendazole: It has a broad-spectrum deworming activity, and has a strong killing effect on nematodes, tapeworms and trematodes. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms. [0003] Ivermectin: It has a good repellent effect on internal and external parasites, especially arthropod insects and internal nematodes, and is mainly used to expel gastrointestinal nematodes, lung nematodes and external parasites in pigs. Its deworming mechanism is to promote the release of γ-aminobutyric acid (GABA) from presynaptic neurons, thereby opening the GABA-mediated chloride ion channel. The chlo...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4184A61K9/16A61K47/36A61K47/26A61K47/04A61K47/24A61K47/44
CPCA61K9/1611A61K9/1617A61K9/1623A61K9/1652A61K31/4184A61K31/7048A61K2300/00
Inventor 刘肖娟谭志坚翁亚彪符德文袁增辉黎剑坤陈艺青
Owner FOSHAN STANDARD BIO TECH
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