Application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis

Abstract

The invention discloses an application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis. In fluid resuscitation, through the application of the combination of the furosemide and and dexamethasone in coordination with natural plasma (human plasma), fluid balance is achieved and parenteral nutrition is supplemented, and meanwhile, capillary leakage is reduced and intra-abdominal hypertension and acute inflammatory reaction are relieved; after the fluid resuscitation, in coordination with parenteral nutrition, early intestinal perfusion is conducted by virtue of a nasal jejunal feeding tube, so as to promote intestinal peristalsis and also to maintain intestinal mucosa nutritional substrate; therefore, the biggest lymph laboratory of human body is kept stable, atrophy and bacterial translocation of the lymph laboratory are relieved, exhaustion and defecation are promoted and abdominal distension is relieved; and in addition, intravenous medication and liquid amount can be obviously reduced, and transformation from fluid balance to negative-water balance is achieved so as to protect organ functions and to relieve the occurrence of complications.

Description

technical field [0001] The invention relates to the treatment of early severe acute pancreatitis, in particular to the application of furosemide combined with dexamethasone in the treatment of early severe acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a local inflammatory reaction caused by pancreatic self-digestion after the activation of pancreatic enzymes. Clinically, it can be divided into mild acute pancreatitis (MAP) and severe acute pancreatitis. (sever acute pancreatitis, SAP). Among them, severe acute pancreatitis has multiple pathogenesis factors, numerous complications, critical condition, pancreatic hemorrhage and necrosis, and extremely high case fatality rate. [0003] According to the "Severe Acute Pancreatitis Diagnosis and Treatment Draft" drafted by the Pancreatic Surgery Group of the Surgery Branch of the Chinese Medical Association in 2000, the whole course of SAP is divided into 3 phases: (1) Acute reaction phase, from the...

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Problems solved by technology

[0005] However, in acute pancreatitis, due to the increase of vascular permeability and the decrease of colloid osmotic pressure, extracellular fluid will penetrate into the peripancreatic space, retroperitoneum, peritoneal cavity, and pleural cavity, resulting in a large loss of circulating blood volume. Fluid resuscitation will not improve the patient's prognosis, but will aggravate the patient's condition

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