Preparation method of pharmaceutical composition for improving safety of compound ginseng injection

An injection and safety technology, applied in the field of medicine, can solve the problems of polysorbate 80 being easily rancid, accelerating the pH value of the liquid medicine, and decreasing the pH value of the solution, and achieving the effects of improving safety, good safety and high dosage

Inactive Publication Date: 2017-02-01
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Preparation method of pharmaceutical composition for improving safety of compound ginseng injection
  • Preparation method of pharmaceutical composition for improving safety of compound ginseng injection
  • Preparation method of pharmaceutical composition for improving safety of compound ginseng injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: decoct ginseng and red ginseng in water twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to reduce the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Dijincao is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and allowed to cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure to...

Embodiment 2

[0029]

[0030] Preparation method: decoct ginseng and red ginseng in water twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to reduce the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Dijincao is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and allowed to cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure to...

Embodiment 3

[0032]

[0033]Preparation method: decoct ginseng and red ginseng in water twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to reduce the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Dijincao is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and allowed to cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure to ...

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Abstract

The invention discloses a preparation method of a pharmaceutical composition for improving safety of a compound ginseng injection. The pharmaceutical composition is mainly prepared from ginseng extract, salvia extract, humifuse euphorbia herb extract and polyethylene glycol 15-hydroxystearic acid, and used for injection. The preparation method of the pharmaceutical composition uses cosolvent good in safety and obvious in dissolving aiding effect for replacing cosolvent polysorbate 80 in the compound ginseng injection, which has potential safety hazards and influences product quality, and the polyethylene glycol 15-hydroxystearic acid has safely higher than the cosolvent polysorbate 80, and furthermore the usage amount of the polyethylene glycol 15-hydroxystearic acid is lower than that of the cosolvent polysorbate 80, and therefore a probability and risk of adverse effects of drugs are reduced, and safety of clinical medication is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a pharmaceutical composition for improving the safety of compound ginseng injection. Background technique [0002] The standard of compound ginseng injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine). The raw materials are ginseng, salvia miltiorrhiza, and Dijincao, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound ginseng injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reaction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K47/14A61K9/08A61K9/19A61P29/00A61P15/00
CPCA61K36/258A61K9/0019A61K9/08A61K9/19A61K36/47A61K36/537A61K47/14A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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