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Preparation method of hydrogel with microfluid channel

A microfluidic channel and hydrogel technology, which is applied in the field of hydrogel preparation, can solve the problems that PDMS microfluidic channel requires high conditions, does not have to meet biomimetic conditions, and the price of collagen is high, and achieves saving preparation time and microfluidic channel. The effect of convenience and short preparation time

Active Publication Date: 2017-01-25
SHENZHEN MICRO & NANO INTEGRATED CIRCUITS & SYST RES INST
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Problems solved by technology

[0010] However, the disadvantages of the above hydrogel preparation methods are: collagen is expensive and difficult to store, and it is not necessary to achieve sufficient biomimetic conditions under many conditions, and the conditions for preparing PDMS microfluidic channels are relatively high, costly, and expensive. duration

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  • Preparation method of hydrogel with microfluid channel
  • Preparation method of hydrogel with microfluid channel
  • Preparation method of hydrogel with microfluid channel

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Embodiment Construction

[0027] The technical solutions of the present invention will be further described in more detail below in conjunction with the accompanying drawings and specific embodiments. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0028] figure 1 It is a schematic flowchart of the preparation method of the hydrogel with microfluidic channel provided by the embodiment of the present invention. Such as figure 1 Shown, the preparation method of the hydrogel with microfluidic channel provided by the present invention comprises the following steps:

[0029] Step S102: Place a silicon-based microstructure film with a target pattern on the substrate, mix the polydimethylsiloxane (PDMS) prepolymer and the curing ag...

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Abstract

The invention discloses a preparation method of hydrogel with a microfluid channel. The preparation method of the hydrogel with the microfluid channel is characterized by comprising the following steps: (1) placing a silica-based microstructure film with a targeted pattern on a substrate, uniformly mixing polydimethylsiloxane (PDMS) prepolymer and a curing agent according to the mass ratio of 10:1, pouring a solution on the substrate, curing for 1 hours at the temperature of 100 DEG C, taking out and then cooling at room temperature, and after cooling, separating a silica base from a PDMS template to obtain a PDMS microfluid channel template of the targeted pattern; (2) bonding the PDMS microfluid channel template in the step (1) on a glass slide, and preparing a gelatin and hydrogel sacrificial template; and (3) preparing polyacrylamide (PAM) hydrogel to obtain PAM hydrogel of the microfluid channel with the targeted pattern. By the preparation method of the hydrogen with the microfluid channel, the hydrogen of the microfluid channel with the targeted pattern can be prepared quickly, and the industrial manufacturing cost is low.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a method for preparing hydrogel with microfluidic channels. Background technique [0002] Microfluidic chip, also known as Lab on a chip, was developed from the field of analytical chemistry in the 1990s. It is a typical application of micro-electromechanical processing technology (MEMS), with micro-pipe network as the structural feature and micro-fluid as the core, it can realize a series of sample purification, reaction, extraction, separation and detection involved in the field of biology or chemistry. Functional experimental device, so as to realize the overall miniaturization, integration, automation and portability of samples from pretreatment to detection. Microfluidic chips can be divided into glass chips, silicon chips, quartz chips, polymer chips and composite material chips according to the different materials used to make them. Among them, polymer mater...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/56C08F222/38C08J3/28C08J3/24C08L33/26C08L71/02
CPCC08F220/56C08J3/075C08J3/24C08J3/28C08J2333/26C08J2371/02C08F222/385
Inventor 王欣择马乾力王丹
Owner SHENZHEN MICRO & NANO INTEGRATED CIRCUITS & SYST RES INST
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