JAK kinase inhibitor with 4-amino-(1H)-pyrazole structure and preparation method and application thereof
A kinase inhibitor, pyrazole technology, applied in the field of organic compound synthesis and pharmaceutical applications, can solve the problem of undisclosed powerful inhibitors
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[0087] The terms and definitions used in this document have the following meanings:
[0088] "Alkanes" refer to C1-C6 aliphatic chains, such as cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane and the like.
[0089] "Aryl" refers to a group containing an aromatic carbocyclic ring and a substituted aryl group with substituents on the ring. The preferred aromatic ring contains 6-10 carbon atoms.
[0090] HEL cells are human leukemia cells, MCF-7 cells are human breast cancer cells, PC-3 cells are prostate cancer cells, K562 are human myeloid leukemia cells, and MOLT4 cells are human lymphoma leukemia cells. These cells are widely used in tumors Research, biological experiments or cell culture, has become a very important tool in medical research.
[0091] 3. Application of JAK kinase inhibitors containing 4-amino-(1H)-pyrazole ring structure
[0092]Activity screening experiments show that the compound of the present invention has good inhibitory activity of ...
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