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Bioactive porous ceramic tubular bar material as well as preparation method and application thereof

A porous ceramic and bioactive technology, applied in the field of medical biomaterials, can solve the problems of slow degradation, and achieve the effects of promoting vascularization, excellent biological activity, cell migration and osteogenesis

Active Publication Date: 2017-01-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been found that magnesium calcium olivine also has excellent biological activity, but the degradation is extremely slow

Method used

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  • Bioactive porous ceramic tubular bar material as well as preparation method and application thereof
  • Bioactive porous ceramic tubular bar material as well as preparation method and application thereof
  • Bioactive porous ceramic tubular bar material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1) Put the diopside powder into a ball mill and mill it for 6 hours, then sieve it to obtain an ultrafine powder with a particle size of less than 60 μm, and then stir and disperse the ultrafine powder at a solid-to-liquid mass ratio of 1:2 to a concentration of In 6% polyvinyl alcohol aqueous solution, a two-phase uniform paste is formed, and then the paste slurry is placed in the injection reservoir of the write-in 3D printer, and the shape of the honeycomb channel is set (as attached figure 1 ), the diameter of the central hole channel is 2.6mm, the diameter of the rod is 42mm, and the porosity is set to 24%, 50% and 84% respectively according to 50%, 30% and 20% of the length of the rod, start the printing equipment, press Carry out three-dimensional printing to form a tubular porous rod with an outer diameter and an inner diameter of 42mm and 2.6mm respectively, then dry the tubular porous rod at 60°C for 12 hours, and sinter at 1300°C for 4 hours to obtain a porous...

Embodiment 2

[0066] The preparation method is the same as in Example 1, the difference is that in step 1), the superfine powder is stirred and dispersed into the polyvinyl alcohol aqueous solution with a concentration of 3% at a solid-to-liquid mass ratio of 1:1, and 55% of the length of the rod is used. , 30% and 15% respectively set the porosity to 21%, 55% and 81%, start the printing equipment, press to perform three-dimensional printing, and form a tubular porous rod with an outer diameter and an inner diameter of 42mm and 11.2mm respectively, and obtain after sintering Diopside porous ceramic tubes with outer diameter and inner diameter of 40mm and 10mm respectively; the raw material composition for preparing the calcium magnesium silicate modification layer in step 2) is adjusted to: 0.1mol ethyl orthosilicate is dissolved in 1000ml deionized water , then add 1ml of nitric acid and stir for 15 minutes, then add 0.7mol calcium nitrate and 0.1mol magnesium nitrate, stir and hydrolyze fo...

Embodiment 3

[0068] The preparation method is the same as in Example 1, the difference being that the porosity is set to 35%, 50% and 65% respectively according to 65%, 20% and 15% of the rod length in step 1), and the calcium prepared in step 2) The raw material composition of the magnesium silicate modification layer is adjusted as follows: dissolve 0.40mol tetraethyl orthosilicate in 90ml deionized water, then add 2ml nitric acid and stir for 15 minutes, then add 0.4mol calcium nitrate and 0.016mol magnesium nitrate, at room temperature Stirring and hydrolysis for 60 minutes, aging for 24 hours, the mixed solution is converted into a hydrogel, the diopside porous ceramic tube prepared in step 1) is placed in the gel, and the negative pressure suction is impregnated, and the porous ceramic tubular rod is taken out, Then use vacuum filtration to suck out the excess gel in the pores, continue to age for 36 hours, dry at 95°C for 36 hours, calcinate at 950°C for 2 hours, and cool naturally. ...

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Abstract

The invention discloses a bioactive porous ceramic tubular bar material as well as a preparation method and application thereof. The bioactive porous ceramic tubular bar material comprises a non-biodegradable calcium magnesium silicate porous ceramic tube and a biodegradable calcium magnesium silicate modified layer, wherein the biodegradable calcium magnesium silicate modified layer is modified by calcium magnesium silicate, subjected to sintering treatment and then cover the pore channel wall of the porous ceramic tube. The preparation method comprises the following steps: performing mixing treatment on tetraethoxysilane, calcium salt, magnesium salt, nitric acid and trace element inorganic salt or acid to obtain hydrogel; putting the pre-built calcium magnesium silicate porous ceramic tube into the hydrogel, dipping, sucking, ageing, drying, calcining and cooling to obtain the bioactive porous ceramic tubular bar material. The tubular bar material provided by the invention can decompress a femoral head necrosis medullary core for a long time, can significantly improve vascularization and nutrient transmission of a necrotic area and can promote new bone regeneration of bone injury; the tubular bar material has excellent bioactivity and has application value in femoral head necrosis and defected bone remodeling of a large bone.

Description

technical field [0001] The invention relates to medical biomaterials, in particular to a bioactive porous ceramic tubular rod, a preparation method and application thereof. [0002] technical background [0003] Avascular necrosis of the femoral head (abbreviated as femoral head necrosis) is a bone and joint disease characterized by the interruption or damage of blood supply to the femoral head, resulting in the death of bone cells and bone marrow components. Sick and disabled. The etiology of femoral head necrosis is complex and difficult to treat, which has always been a difficult problem in orthopedics. Its disability rate is high, and it mainly affects young adults aged 30 to 50, which brings a heavy burden to the patients themselves and the society. [0004] Due to the rapid progress of femoral head necrosis, if it is not detected in time or the treatment is improper, the long-term disability rate is extremely high, and it usually progresses to femoral head collapse wit...

Claims

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Application Information

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IPC IPC(8): C04B41/85
Inventor 苟中入何冬霜杨贤燕柳丽敏
Owner ZHEJIANG UNIV
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