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Degradable porous glass rack having bioactivity and preparation method

A bioactive glass, glass technology, applied in glass manufacturing equipment, glass molding, manufacturing tools and other directions, can solve the problems of poor applicability of stent materials, affecting the use effect, easy to break, etc., to achieve good biological interface and chemical properties, The effect of good biological activity, good degradability

Active Publication Date: 2006-08-16
KUNSHAN CHINESE TECH NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research results show that when the compressive strength is less than 1MPa, the applicability of the scaffold material is poor, and it is easily damaged when used as a cell scaffold or bone damage repair material, which greatly affects the use effect
No report on the compressive strength index of porous bioactive glass scaffolds was found in the previous patent literature

Method used

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  • Degradable porous glass rack having bioactivity and preparation method
  • Degradable porous glass rack having bioactivity and preparation method
  • Degradable porous glass rack having bioactivity and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The raw materials used are as described above.

[0042] will analyze pure SiO 2 , Na 2 CO 3 , CaCO 3 , P 2 o 5 The raw materials are uniformly mixed in proportion, melted into a homogeneous melt at 1420°C, then cooled, pulverized, and sieved to obtain bioactive glass powder with a particle size of 40-300um. The composition of the glass powder is CaO 24.5%, SiO 2 45%, Na 2 O 24.5%, P 2 o 5 6%.

[0043] Mix the bioactive glass powder with a particle size of 150-200 microns and the polyethylene glycol powder with a particle size of 200-300 microns at a mass percentage of 60:40, and add a polyvinyl alcohol solution with a concentration of 6% as a binder. After mixing evenly, dry press molding under 14MPa pressure, and release the biscuit of porous material. The green compact is ejected at 400° C., and then sintered at 850° C. for 2 hours to obtain the porous material of the present invention with a compressive strength of about 1.25 MPa and a porosity of about 5...

Embodiment 2

[0046] will analyze pure SiO 2 , CaCO 3 , Ca 3 (PO 4 ) 2 , MgCO 3 , CaF 2 The raw materials are uniformly mixed in proportion, melted into a homogeneous melt at 1450°C, then cooled, pulverized, and sieved to obtain bioactive glass powder with a particle size of 40-300um. The composition of the glass powder is CaO 40.5%, SiO 2 39.2%, MgO 4.5%, P 2 o 5 15.5%, CaF 2 0.3%.

[0047] The obtained powder is mixed according to the mass percentage of bioactive glass powder and 300-600 micron polyvinyl alcohol powder in a ratio of 50:50 to obtain a solid mixture. Prepare an aqueous solution containing 20% ​​acrylamide, 2% N, N'-methylenebisacrylamide and 8% polyacrylamide, mix 10 grams of the above-mentioned solid mixture with the above-mentioned aqueous solution at a ratio of 50:50 by volume Mix evenly, add a few drops of 3% ammonium persulfate by mass percent and 3% by mass percent N, N, N', N'-tetramethylethylenediamine, stir evenly to obtain a slurry with good fluidity...

Embodiment 3

[0049] The raw materials used and the preparation method of the bioactive glass powder are the same as in Example 2.

[0050] Mix bioactive glass powder with a particle size of 150-200 microns and PEG powder with a particle size of 200-300 microns at a mass ratio of 40:60, add polyvinyl alcohol solution with a concentration of 6% as a binder, and mix well. Dry press molding under 14MPa pressure, demoulding the biscuit of porous material. The green body is ejected at 400°C and then sintered at 800°C to obtain the porous material of the present invention with a compressive strength of about 1.5 MPa and a porosity of about 65%. After soaking in simulated body fluid for 3 days, the degradation rate was 38% (mass percentage of dissolved Si). The performance evaluation of the porous material is as in Example 1. It can be used as a scaffold for bone tissue culture in vitro.

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Abstract

The compounds of glass frame are: (mol%) CaO 24-45, SiO2 34-50, Na2O 0-25, P2O5 5-17, MgO 0-5 and CaF2 0-1. Volume percentage of porosity is 40-80, aperture is 50-600 um. Biological active glas powder produced by melting method is used as raw material, adding organic or high polymer pore-forming agent with different granularities in, cellular material biscuit is formed by dry pressing or gel injection molding after mixing, the biscuit is roasted on proper raising temp. to produce degradated cellular biological active glass frame that mechanics strength, prosity and hole size can be controlled. There is hydroxyl kietyoite generated on surface of said frame after the frame is steeped in human body analog humor, it has good biological activity and can be used as hard tissue defect repairing material and cell frame material for in vitro bone tissue cultivating.

Description

technical field [0001] The invention relates to a porous degradable bioactive glass support material used for hard tissue repair and as a tissue engineering cell support and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] Since Hench first reported that bioactive glass can bond with bone tissue in 1971 (1), the research on bioactive glass has a history of more than 30 years. It has been used clinically for more than ten years as a bone defect repair. The successful clinical application comes from its not only osteoconductivity, but also the biological activity of promoting bone tissue growth. Many recent studies have shown that the degradation products of bioactive glass can promote the production of growth factors, promote the proliferation of cells, and activate the gene expression of osteoblasts. Not only that, but bioactive glass is currently the only artificial biomaterial that can bond to both bone tissue an...

Claims

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Application Information

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IPC IPC(8): C03C3/062C03C3/076C03C3/078C03C3/097C03C3/112C03C11/00C03B19/09C12N11/14A61F2/02
CPCC03C11/00C03C3/062C03C3/097C03C3/112
Inventor 常江顾卫明钟吉品
Owner KUNSHAN CHINESE TECH NEW MATERIALS CO LTD
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