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Trollflower injection and preparation method thereof

A technology of injection and nasturtium, applied in the field of injection, can solve the problems of slow onset of effect and long course of treatment, and achieve the effects of rapid onset of effect, shortened course of treatment, and improved bioavailability

Inactive Publication Date: 2017-01-25
威海恒基伟业信息科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many common problems in oral Chinese medicine preparations at present: the treatment course of Chinese medicine is long and the onset is slow, because the destruction of the active ingredients of the medicine by the metabolic factors of the human body cannot be avoided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: (1) Take 1 kg of nasturtium, add 10 kg of water, decoct for 0.5-2 hours, filter, add water to decoct the medicinal residues, repeat 2-5 times, combine the filtrates, concentrate under reduced pressure to contain nasturtium 1- 5g / ml;

[0023] Add ethanol to make the alcohol content reach 60-70%, let stand at 0-10°C for 20-60 hours, filter, recover ethanol under reduced pressure, and concentrate to contain nasturtium nasturtium 3-8g / ml;

[0024] Then add ethanol to make the alcohol content reach 75-85%, let stand at 0-10°C for 8-24 hours, filter, recover ethanol under reduced pressure, and concentrate to contain nasturtium nasturtium 8-12g / ml;

[0025] Dilute with water to contain 3-5g / ml of nasturtium nasturtium;

[0026] (2) Use macroporous resin for column packing, elution and separation, eluent water and 30-50% ethanol are respectively 2 times the amount of macroporous resin, and ethanol eluent is collected;

[0027] (3) Recover the ethanol eluent under r...

Embodiment 2

[0033] The difference between embodiment 2 and embodiment 1 is as follows:

[0034] (1) Get 5 kg of nasturtium, add 75 kg of water; (2) The eluent water and 30-50% ethanol are respectively 8 times the amount of macroporous resin.

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Abstract

The invention relates to a trollflower injection and a preparation method thereof. The trollflower injection is injection prepared from trollflower extracts and pharmacological active ingredients; the injection has the concentration that 10g of trollflower raw medicine is contained in 10ml of injection. The preparation process of the injection comprises the following steps that (1) trollflowers are decocted after water addition and are filtered; filtrate is subjected to pressure reduction concentration; ethyl alcohol is added for still standing, and filtrate is concentrated; (2) water is added for dilution, and macroporous resin is used for elution separation; (3) activated carbon is added into collected ethyl alcohol eluant; heating and stirring are performed; filtering is performed for removing carbon; (4) the pH value is regulated to 7.0 to 7.5; an isotonic agent is added and regulated; finally, water for injection is added for dilution until 10g of trollflower raw medicine is contained in 10ml of injection. The trollflower injection has the beneficial effects that the bioavailability of the trollflower injection is greatly improved through being compared with that of a traditional trollflower oral preparation; the effect taking speed is high; in addition, the treatment course is shortened.

Description

technical field [0001] The invention relates to an injection made from active ingredients extracted from Chinese herbal medicines, which is suitable for treating acute appendicitis, bacillary dysentery, upper respiratory tract infection, urinary system infection and the like. The invention also relates to a preparation method of the injection. Background technique [0002] Trollius is the dried flower of Trollius chinernsis bunge, a plant of Ranunculaceae. It is clinically used to treat acute appendicitis, bacillary dysentery, upper respiratory tract infection, urinary system infection, etc., with good curative effect and small side effects. Relevant data show that flavonoids are the main components of the antibacterial effect of nasturtium. The flavonoids contained in its organisms mainly include: orientin, vitexin and so on. At the same time, the ingredients with pharmacological effects include substances such as alkaloids. [0003] At present, the domestic existing ph...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/08A61P1/00A61P1/12A61P31/04A61P11/00A61P13/00
CPCA61K36/71A61K9/08A61K2236/331A61K2236/53
Inventor 蔡颖
Owner 威海恒基伟业信息科技发展有限公司
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