Method for screening pesticide and veterinary drugs in infant formula food by ultra-high performance liquid chromatography-quadrupole static electric field track ion trap mass spectrum

Abstract

The invention discloses a method for screening pesticide and veterinary drugs in infant formula food by ultra-high performance liquid chromatography-quadrupole static electric field track ion trap mass spectrum, and belongs to the technical field of food safety inspection. The method comprises the following steps: preprocessing a sample by an optimized QuEChERS method; screening by applying ultra-high performance liquid chromatography-quadrupole static electric field track ion trap mass spectrum; selecting a positive ion or negative ion mode for scanning by adopting full-scan / data dependence acquisition, full-scan / variable data independence acquisition and full-scanning / full-ionic acquisition fragmentation acquisition scan modes to obtain complete primary and secondary maps; and processing the primary and secondary maps by applying Exact Finder 2.5 software to extract compound information. According to the method, information in the established spectrum library is compared with the screening result of a to-be inspected object so as to ensure the composition of pesticide and veterinary drugs in an infant formula food. The mass spectrum instrument used in the method has the main advantages of high resolution ratio, accurate qualitative and quantitative results, high sensitivity, high quality precision and the like. The method can be applied to analysis of complex substrates.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of food safety detection, and in particular relates to an ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for pesticides and veterinary drugs in formula food for infants and young children. [0003] 【Background technique】 [0004] Infant formula food refers to the liquid or powder food produced and processed with milk or soybean and its processed products as the main raw material, adding appropriate amount of vitamins and minerals, etc., suitable for normal infants. With the improvement of living standards, people pay more and more attention to the safety of infant formula food. Pesticides and veterinary drugs, as exogenous substances in infant formula food, will cause certain harm to the human body. On October 1, 2015, the newly revised "Food Safety Law of the People's Republic of China" was officially implemented. The ...

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Problems solved by technology

[0007] However, at present, there are few high-throughput and rapid detection methods for exogenous risk substances in infant formula foods, the pre-treatment operations are complicated, and the cost of materials and equipment is high, which is limited to the rapid detection of several or one type of compounds

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