Preparation method of orange magnoliavine fruit lignan extract

Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a preparation method of orange magnoliavine fruit lignan. According to the preparation method of the orange magnoliavine fruit lignan, reflux extraction is performed on an orange magnoliavine fruit medicinal material with an ethanol aqueous solution, a loading solution is prepared and passes a weakly polar macroporous resin adsorption column, elution for impurity removal is performed with 10%-30% of ethanol, then elution is performed with 70%-90% of ethanol, an ethanol eluent is collected and passes an alumina adsorption column with the weight 0.5-2 times that of the medicinal material, effluent is collected, a solvent is recovered under the reduced pressure or normal pressure, reduced pressure or normal pressure drying is performed at 60-100 DEG C, and the orange magnoliavine fruit lignan extract is obtained. The extraction efficiency is improved, liquid discharge is smooth, mass production compliance is substantially improved, the production time is substantially shortened, and the production cost is saved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a lignan extract from Schisandra chinensis and a preparation method thereof. Background technique [0002] Schisandra sphenanthera is the dry and mature fruit of Schisandra sphenanthera Rehd. et Wils., a plant of Magnoliaceae, and is an important commonly used traditional Chinese medicine. It has the effects of astringent and astringent, nourishing qi and promoting body fluid, nourishing the kidney and calming the heart, and is used for chronic cough and dyspnea, nocturnal emission, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirsty body fluid wound, short breath and pulse deficiency, internal heat and quenching thirst, Palpitations and insomnia. [0003] Lignans are the main active ingredients of Schisandra chinensis. It has been reported in the literature that it has pharmacological activities such as anti-cancer...

AI Technical Summary

Problems solved by technology

During the implementation of this method, it was found that it is not suitable for large-scale production operations. Since Schisandra chinensis is a fruit-like medicinal material, after water distillation and water decoction, the medicinal material is easy to gelatinize, and it is difficult to drain the liquid, which hinders production. , when adding ethanol for extraction, the actual ethanol concentration decreases, resulting in a low extraction rate of active ingredient lignans; the macroporous adsorption resin is a polar resin, and both the sample liquid and the eluent are collected, and there is no impurity removal and elution step, so the purification effect is limited. The final extraction rate and effective part content are both low, and better methods are needed to meet the smooth progress of large-scale production, and to increase the content and yield of active ingredients in the extract

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